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OBJECTIVE To evaluate the role of in vivo corneal tandem scanning confocal microscopy (TSCM) in the definitive diagnosis of suspected Acanthamoeba keratitis (AK). DESIGN Noncomparative interventional single-institution case series. METHOD A retrospective case review of patients consecutively referred with suspected AK and undergoing corneal TSCM was(More)
PURPOSE To compare the corneal higher-order aberration (HOA) after Descemet's stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PKP), and in age-matched controls. DESIGN Cross-sectional, non-comparative interventional case series. PARTICIPANTS Thirty-one eyes of 28 patients who underwent DSAEK, 20 eyes of 16 patients who(More)
PURPOSE To derive regression-based formulas and identify essential dependent variables to estimate refractive corneal power after myopic laser in situ keratomileusis (LASIK). SETTING University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. METHODS A retrospective data review of 30 eyes (23 patients) having myopic LASIK followed by(More)
Computational imaging enables retrieval of the spatial information of an object with the use of single-pixel detectors. By projecting a series of known random patterns and measuring the backscattered intensity, it is possible to reconstruct a two-dimensional (2D) image. We used several single-pixel detectors in different locations to capture the 3D form of(More)
PURPOSE To evaluate the resolution of contact lens-induced corneal warpage before keratorefractive surgery. METHODS We prospectively studied the eyes of 165 consecutive contact lens-wearing patients evaluated for keratorefractive surgery. Significant contact lens-induced corneal warpage was detected by comeal topography in 20 eyes of 11 patients.(More)
OBJECTIVE To determine the reliability of intraocular pressure (IOP) measurements by Goldmann applanation tonometry and pneumotonometry in eyes treated with excimer myopic photorefractive keratectomy (PRK). DESIGN A prospective case series. PARTICIPANTS Forty consecutive eyes treated with PRK were evaluated. INTERVENTION AND MAIN OUTCOME MEASURES(More)
The phenomenon of light's momentum was first observed in the laboratory at the beginning of the twentieth century, and its potential for manipulating microscopic particles was demonstrated by Ashkin some 70 years later. Since that initial demonstration, and the seminal 1986 paper where a single-beam gradient-force trap was realized, optical trapping has(More)
Coupling noble metal nanoparticles by a 1 nm gap to an underlying gold mirror confines light to extremely small volumes, useful for sensing on the nanoscale. Individually measuring 10 000 of such gold nanoparticles of increasing size dramatically shows the different scaling of their optical scattering (far-field) and surface-enhanced Raman emission (SERS,(More)
Open source hardware has the potential to revolutionise the way we build scientific instruments; with the advent of readily available 3D printers, mechanical designs can now be shared, improved, and replicated faster and more easily than ever before. However, printed parts are typically plastic and often perform poorly compared to traditionally machined(More)
We investigate the effects of 1(st) order spherical aberration and defocus upon the stiffness of an optical trap tens of μm into the sample. We control both these aberrations with a spatial light modulator. The key to maintain optimum trap stiffness over a range of depths is a specific non-trivial combination of defocus and axial objective position. This(More)