Richard Vandaele

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Solution-phase synthesis and evaluation of a library of 31 sulfonamides as inhibitors of a chloroquine-resistant strain of Plasmodium falciparum are described. The most potent compound displayed an activity 100-fold better than chloroquine. Experiments using a fluorescent sulfonamide derivative suggest that their site of action inside the parasite is(More)
Plasmacytoid monocytes are normal cell constituents of the human lymph node and have been found to form perivascular clusters in a case of lymphocytic infiltration of the skin. This study was undertaken to analyze the occurrence of plasmacytoid monocyte clusters in biopsy specimens from 54 patients with lymphocytic infiltration of the skin using light(More)
Synthesis and evaluation of the activity of a new family of 1,4-bis(3-aminopropyl)piperazine derivatives against a chloroquine-resistant strain of Plasmodium falciparum, and as inhibitors of beta-hematin formation, are described. The highest antimalarial activities were obtained for compounds displaying the highest predicted vacuolar accumulation ratios and(More)