Richard T. George

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Left ventricular remodeling during the development of heart failure is a strong predictor of cardiovascular mortality. However, methods to objectively quantify remodeling-associated shape changes are not routinely available but may be possible with new computational anatomy tools. In this study, we analyzed and compared multi-detector computed tomographic(More)
In this study, we used the multi-detector computed tomographic (MDCT) images of heart left ventricles at end-diastole and end-systole to perform quantitative analysis and comparison of heart motion in patients with anterior wall myocardial infarction and ischemic cardiomyopathy (ICM) versus those with global non-ischemic cardiomyopathy (NICM). MDCT(More)
In the present study, we investigate the hemodynamics inside left atrium (LA) and understand its impact on the development of ventricular flow patterns. We construct the heart model using dynamic-computed tomographic images and perform simulations using an immersed boundary method based flow solver. We show that the atrial hemodynamics is characterized by a(More)
The objective of this study was to investigate the impact of image acquisition settings and patients' characteristics on image quality and radiation dose for coronary angiography by 320-row computed tomography (CT). CORE320 is a prospective study to investigate the diagnostic performance of 320-detector CT for detecting coronary artery disease and(More)
The proliferation of four‐dimensional imaging technologies, increasing computational speeds, improved simulation algorithms, and the widespread availability of powerful computing platforms is enabling simulations of cardiac hemodynamics with unprecedented speed and fidelity. Since cardiovascular disease is intimately linked to cardiovascular hemodynamics,(More)
Recent computed tomography coronary angiography (CCTA) studies have noted higher transluminal contrast agent gradients in arteries with stenotic lesions, but the physical mechanism responsible for these gradients is not clear. We use computational fluid dynamics (CFD) modeling coupled with contrast agent dispersion to investigate the mechanism for these(More)
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