Richard Schneider

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The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene. Here we report the discovery of 109 (CCT251921), a potent, selective, and orally bioavailable inhibitor of CDK8 with equipotent affinity for CDK19. We describe a(More)
There is unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545, a small-molecule inhibitor of the WNT pathway discovered through cell-based screening, is a potent and selective chemical probe for the human Mediator complex-associated(More)
Smartphones and tablets are increasingly used to access the Web, and many websites now provide alternative sites tailored specifically for these mobile devices. Web archivists are in need of tools to aid in archiving this equally ephemeral Mobile Web. We present Findmobile, a tool for automating the discovery of mobile websites. We tested our tool in an(More)
An automated visual inspection system has been developed for use with surface mount devices (SMDs) on a printed circuit board (PCB). The system is capable of inspecting minute solder joints of fine pitch components as small as 0.3mm pitch QFP leads. A solder joint is judged using a height image and an intensity image that are detected by a unique confocal(More)
Recent studies have shown that conservation gains can be achieved when the spatial distributions of biological benefits and economic costs are incorporated in the conservation planning process. Using Alberta, Canada, as a case study we apply these techniques in the context of coarse-filter reserve design. Because targets for ecosystem representation and(More)
Habitat protection has been identified as an important strategy for the conservation of woodland caribou (Rangifer tarandus). However, because of the economic opportunity costs associated with protection it is unlikely that all caribou ranges can be protected in their entirety. We used an optimization approach to identify reserve designs for caribou in(More)
Ecosystem distributions are expected to shift as a result of global warming, raising concerns about the long-term utility of reserve systems based on coarse-filter ecosystem representation. We tested the extent to which proportional ecosystem representation targets would be maintained under a changing climate by projecting the distribution of the major(More)
Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors. We discovered two series of potent chemical probes with high selectivity for CDK8/19. Despite pharmacodynamic(More)
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