Richard S. Middleton

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Spatializations are computer visualizations in which nonspatial information is depicted spatially. Spatializations of large databases commonly use distance as a metaphor to depict semantic (nonspatial) similarities among data items. By analogy to the " first law of geography " , which states that closer things tend to be more similar, we propose a " first(More)
Dimensionality reduction algorithms are applied in the field of information visualization to generate low-dimensional, visuo-spatial displays of complex, multivariate databases—spatializa-tions. Most popular dimensionality reduction algorithms project relatedness in data content among entities in an information space (e.g., semantic similarity) onto some(More)
As GIScientists we know that " Everything is related to everything else, but near things are more related than distant things " (Tobler, 1970: 236). Unfortunately this law does not tell the spatially aware researcher how to conceptualize " nearness " or which proximity measure to utilize to quantify " relatedness ". One of the main challenges in GIScience(More)
Carbon dioxide capture and storage (CCS) links together technologies that separate carbon dioxide (CO 2) from fixed point source emissions and transport it by pipeline to geologic reservoirs into which it is injected underground for long-term containment. Previously, models have been developed to minimize the cost of a CCS infrastructure network that(More)
In this paper, we describe our experience with solving difficult mixed-integer linear programming problems (MILPs) on the petaflop Cray XT5 system at the National Center for Computational Sciences at Oak Ridge National Laboratory. We describe the algorithmic, software, and hardware needs for solving MILPs and present the results of using PICO, an(More)
Seventeen patients ranging in age from 67 to 86 years were entered into a double-blind, crossover study of Moducren and placebo. Psychometric testing using the Clifton Assessment Procedure for the Elderly was performed at the start of the study and at the end of each 4-week test period. The total length of the study was 18 weeks. Apart from effectively(More)
Elastase and lipid levels of the plasmas of subjects and of those who have suffered a stroke have been measured, and it has been shown that the normal age related fall in elastase content is mirrored more closely by the fall in high density lipoprotein cholesterol than by changes in total cholesterol. After a stroke a peak level of the elastase(More)
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