• Publications
  • Influence
Polyglutamine Leads to Altered Chromatin Architecture and Neurodegeneration
In the field of neurodegenerative disease, the so-called polyglutamine diseases hold a unique place. These nine different diseases, which include Huntington disease and several forms ofExpand
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Susceptibility‐Weighted Imaging of the Brain: Current Utility and Potential Applications
Susceptibility‐Weighted Imaging (SWI) is a relatively new magnetic resonance imaging (MRI) sequence relying on susceptibility differences between adjacent tissues to produce an image. It is extremelyExpand
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Unusual variants of Alexander's disease
The purpose of this study was to describe unusual variants of Alexander's disease. We studied 10 patients who did not meet previously established magnetic resonance imaging (MRI) criteria forExpand
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RNAi Therapeutics: How Likely, How Soon?
RNA interference (RNAi) is used in the lab to silence virtually any gene. Previously, antisense and ribozymes were successful in the lab, but have been disappointing in the clinic. Will RNAi succeedExpand
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Vagus nerve stimulation in children with intractable epilepsy: a randomized controlled trial
  • Richard Robinson
  • Medicine
  • Developmental medicine and child neurology
  • 1 February 2013
SIR–Klinkenberg et al. are to be congratulated for publishing the first prospective randomized controlled trial on vagal nerve stimulation in children. The design was similar to that of the initialExpand
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fMRI Beyond the Clinic: Will It Ever Be Ready for Prime Time?
Functional magnetic resonance imaging offers the promise of peeking into the human mind. What signals in the human brain can we really detect and how should the technology be used?
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Ciliate Genome Sequence Reveals Unique Features of a Model Eukaryote
One reason to sequence the genomes of non-human organisms is to better understand our similarities and differences. And, at first sight, it is hard to imagine a eukaryote more different from humansExpand
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Natural Selection Molds Genomic Insulator Elements
The ‘‘modern synthesis’’ of evolutionary biology, first formulated in the early 20th century, combined the ideas of Mendelian genetics and Darwinian evolution to create an outline for evolutionaryExpand
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