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Journals and Conferences
A practical cross-coupling of amides with alkynyl bromides using catalytic CuSO(4).5H(2)O and 1,10-phenanthroline is described here. This catalytic protocol is more environmentally friendly than the use of CuCN or copper halides and provides a general entry for syntheses of ynamides including various new sulfonyl and heteroaromatic amine substituted… (More)
An unexpected stereoselective anomeric substitution with carbamates promoted by HNTf2 is described here. Our experiments suggest that the observed diastereoselectivity is a result of thermodynamic equilibration of protonated N-acyl aminals.
Resveratrol, a nontoxic polyphenol, has been shown to inhibit tumor growth in a xenograft mouse model of neuroblasoma. However, resveratrol is rapidly metabolized, mainly to its glucuronidated and sulfated derivatives. This study demonstrates that resveratrol alone, and not the glucuronidated or sulfated metabolites, is taken up into tumor cells, induces a… (More)
[structure: see text] A stereodivergent approach toward total syntheses of Coccinellidae defensive alkaloids is described. These syntheses feature a highly diastereoselective intramolecular aza-[3 + 3] annulation strategy, which represents a de novo approach to this family of natural products.
Total syntheses of indoloquinolizidine alkaloid (+/-)-, R-(+)-, and S-(-)-deplancheine are described here. The synthesis features an enantioselective intramolecular formal aza-[3 + 3] cycloaddition for the construction of the quinolizidine CD-ring. This application serves to introduce a new synthetic strategy for the synthesis of indoloquinolizidine… (More)
' ./ .' ( ' '0 . ' 1* ( 2 1 . ' 1 * ( * 3 '( 2 4 .( 25 2 ( 2 2 '0 / '/2 ( . / .' ( ' 3 '. 22 2$6 7 00 (1 .( *2 '0 .' 2 * * . ( 2( ( * '2 2 * 3/ ( ' '0 2/. 3 '. 22 2$6 7 * 8 */ . ' 1 * ( 3 ('3 2 4 ' 1 ' ' (' 3 ( 2 .. * 25 '9 8 '2( 1 '/ * 1 .( 2 9 ( ' 1 '9 00 (1 4* 22'. ( ' .' 2( (2 ( (' . ' ' 5 * 3 ( ' * 23 . 0 . (1$6 7 + . 1 22'. ( * .( 2 8 2 8 * 2 ( 2 '… (More)
A computation docking study of the highly potent, non-nitrogen containing, acetylcholinesterase inhibitor (+)-arisugacin A is presented. The model suggests that (+)-arisugacin A is a dual binding site covalent inhibitor of AChE. These findings are examined in the context of Alzheimer's disease-modifying therapeutic design. (+)-Arisugacin A's revealed mode… (More)
A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.
A general approach to synthesis of dihydroxanthone derivatives is described here. In vitro evaluation of these dihydroxanthones demonstrated that some derivatives possess moderate anti-cholinesterase activities and better selectivities than tacrine for acetylcholinesterase over butyrylcholinesterase. Structural effects on anti-cholinesterase activities were… (More)