Richard O. Moore

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Molecular techniques to detect MLL (11q23) and AF-4 (4q21) gene rearrangements are being evaluated for use in stratification of patients into prognostic groups. We studied 15 cases of infant acute lymphoblastic leukemia (ALL) with Southern blotting for MLL gene rearrangement and reverse transcriptase-polymerase chain reaction (RT-PCR) for t(4;11) fusion(More)
In this paper a detailed analysis is made of the phase-sensitive amplification (PSA) of optical pulses by degenerate four-wave mixing (phase-conjugation) in fibers. Formulas are derived, which show that the amplification level and phase sensitivity depend strongly on the phase of the signal pulse, but weakly on its chirp, and the difference between its(More)
We derive a perturbed parametrically forced nonlinear Schrödinger equation to model pulse evolution in an optical parametric oscillator with absorptioninduced heating. We apply both a rigorous renormalization group technique and the formal Wilsonian renormalization group to obtain a low-dimensional system of equations which captures the mutual interaction(More)
We describe in detail the application of importance sampling to numerical simulations of large noise-induced perturbations in soliton-based optical transmission systems governed by the nonlinear Schrödinger equation. The method allows one to concentrate the samples in Monte Carlo simulations around those noise realizations that are most likely to produce(More)
We demonstrate that soliton perturbation theory, though widely used, predicts an incorrect phase distribution for solitons of stochastically driven nonlinear Schrödinger equations in physically relevant parameter regimes. We propose a simple variational model that accounts for the effect of radiation on phase evolution and correctly predicts its(More)