Richard O. Meinecke

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Saturation transfer difference (STD) NMR is a fast and versatile method to screen compound mixtures in the presence of a receptor for binding affinity and to characterize the ligand's binding epitope. Here we demonstrate that ligand interactions with integral membrane proteins can be investigated by STD NMR if the receptor is embedded into the lipid bilayer(More)
9.1 Saturation Transfer Difference NMR Principle ......... " 149 9.2 STD-NMR for Characterizing Ligand Binding to Membrane Integrated Proteins. . . . . . . . . . . . . . . . . . .. 153 9.3 Epitope Mapping with STD-NMR . . . . . . . . . . . . . . . . . .. 157 9.4 Group Epitope Mapping with STD-NMR .............. l57 9.5 Binding Constants from STD-NMR(More)
Strong flurothyl treatment (1.7% v/v for 8 min) produces retrograde amnesia in chicks when administered as long as 24 hr after one-trial avoidance training with a strongly aversive stimulus. Mild flurothyl treatment (0.2% v/v for 8 min) produced retrograde enhancement when administered as long as 16 min after similar training with a moderately aversive(More)
The pit gamecock (Gallus gallus) provides a model of strong trained aggression. A total of 16 aggressive pairs was treated with pentobarbital (40 or 60 mg/kg, intramuscularly), or ethanol (10–30 ml/kg of 33% v/v ethanol, by gastric intubation), or ethanol plus immobilization. Pairs of treated cocks were allowed to recover together in one cage. Fighting(More)
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