Richard Mink

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BACKGROUND AND PURPOSE Hyperbaric oxygen (HBO) has been advocated as a therapy to improve neurological recovery after ischemia, since HBO may improve tissue oxygen delivery. We examined the effect of HBO treatment after global cerebral ischemia on early brain injury. METHODS Rabbits were subjected to 10 minutes of global cerebral ischemia by cerebrospinal(More)
STUDY OBJECTIVE To determine whether adding IV theophylline to an aggressive regimen of inhaled and IV beta-agonists, inhaled ipratropium, and IV methylprednisolone would enhance the recovery of children with severe status asthmaticus admitted to the pediatric ICU (PICU). DESIGN A prospective, randomized, controlled trial. Asthma scoring was performed by(More)
Treatment plans for pediatric septic shock advocate increasing oxygen consumption (VO2). Recent studies in septic shock indicate that improving oxygen delivery (DO2) by increasing blood flow will increase VO2. We prospectively examined the effect on VO2 of improving DO2 by increasing oxygen content (CO2) with blood transfusion in eight hemodynamically(More)
OBJECTIVE To determine whether hyperbaric oxygen administered immediately after global cerebral ischemia increases free radical generation and lipid peroxidation in the brain or alters neurophysiologic recovery. DESIGN Prospective, randomized, controlled trial. SETTING Animal research laboratory. SUBJECTS Adult male New Zealand white rabbits. (More)
OBJECTIVES 1) To compare brain natriuretic peptide levels in pediatric patients with septic shock with both children admitted to the pediatric intensive care unit without infection and with healthy subjects; and 2) to evaluate the correlation between brain natriuretic peptide with severity of illness and with myocardial dysfunction in children with septic(More)
Neurofilaments (NF) and tubulin are highly phosphorylated proteins that are important in neuronal structure and function. Changes in phosphorylation alter their antigenicity, and previous studies examining the effect of ischemia on these proteins failed to consider this factor. Using phosphate-independent antibodies and a quantitative immunoassay, we(More)
Diffuse axonal injury (DAI) secondary to traumatic brain injury (TBI) contributes to long-term functional morbidity. The corpus callosum (CC) is particularly vulnerable to this type of injury. Magnetic resonance spectroscopy (MRS) was used to characterize the metabolic status of two CC regions of interest (ROIs) (anterior and posterior), and their(More)
PURPOSE Following corrective surgery for tetralogy of Fallot (TOF), approximately one-third of these patients develop low cardiac output (CO) due to right ventricular (RV) diastolic heart failure. Extubation is beneficial in these patients because the fall in intrathoracic pressure that occurs with conversion from positive pressure breathing to spontaneous(More)
OBJECTIVE To describe the effects of inhaled nitric oxide on oxygenation and ventilation in patients with acute, hypoxic respiratory failure and to characterize those who respond to low doses with a significant improvement in PaO2. DESIGN Prospective dose response trial of inhaled nitric oxide. Patients who demonstrated a > or =15% improvement in PaO2(More)