Richard Leroy

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For years, external insulin pumps have enjoyed proven efficacy as an intensive diabetes treatment to improve glycaemic control and reduce hypoglycaemia. Since the last ALFEDIAM guidelines in 1995, however, basal-bolus treatment using a combination of long- and short-acting insulin analogues have emerged and could challenge, at a lower cost, the efficacy of(More)
Type 1 diabetes (T1D) is due to the loss of both beta-cell insulin secretion and glucose sensing, leading to glucose variability and a lack of predictability, a daily issue for patients. Guidelines for the treatment of T1D have become stricter as results from the Diabetes Control and Complications Trial (DCCT) demonstrated the close relationship between(More)
We consider the problem of bounding away from 0 the minimum value m taken by a polynomial P ∈ Z [X 1 ,. .. , X k ] over the standard simplex ∆ ⊂ R k , assuming that m > 0. Recent algorithmic developments in real algebraic geometry enable us to obtain a positive lower bound on m in terms of the dimension k, the degree d and the bitsize τ of the coefficients(More)
In this article, we address the question of minimizing a real polynomial over the standard simplex. This problem can be solved with a branch-and-bound method, using the Bernstein form of the polynomial. Such methods have been widely studied from a numerical point of view, and refinements have been proposed to speed up the computational time. We are here(More)
P.-Y. Benhamou, B. Catargi, B. Delenne, B. Guerci, H. Hanaire, N. Jeandidier, R. Leroy, L. Meyer, A. Penfornis, R.-P. Radermecker, E. Renard, S. Baillot-Rudoni, J.-P. Riveline, P. Schaepelynck, A. Sola-Gazagnes, V. Sulmont, N. Tubiana-Rufi, D. Durain, I. Mantovani Coordination: A. Sola-Gazagnes, J.-P. Riveline Société Francophone du Diabète (SFD), Société(More)
Thanks to the high volume of patients'consultations delivered, and especially in private practice, diabetologists are able to accurately describe the expectations of diabetic patients with the new and mostly future technologies. In addition, diabetologists are also able to imagine how these technologies will change their medical practices in future.
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