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The Disposition of Prasugrel, a Novel Thienopyridine, in Humans
Prasugrel was extensively metabolized in humans, first by hydrolysis to a thiolactone, followed by ring opening to form R-138727, which was further metabolized by S-methylation and conjugation with cysteine, suggesting limited penetration of prasug Rel metabolites into red blood cells.
Measured Context‐sensitive Half‐times of Remifentanil and Alfentanil
Background The context‐sensitive half‐time, rather than the terminal elimination half‐life, has been proposed as a more clinically relevant measure of decreasing drug concentration after a constant…
Measured context-sensitive half-times of remifentanil and alfentanil.
BackgroundThe context-sensitive half-time, rather than the terminal elimination half-life, has been proposed as a more clinically relevant measure of decreasing drug concentration after a constant…