Richard L. Wurdeman

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BACKGROUND Contrast-induced nephropathy (CIN) after coronary angiography is associated with increased morbidity and mortality rates. Preliminary studies with N-acetylcysteine (NAC) have found conflicting results in the prevention of CIN in patients undergoing coronary angiography. This study was designed to evaluate the efficacy and safety of NAC in the(More)
BACKGROUND The incidence of supraventricular arrhythmias remains high following open-heart surgery. The most common of these arrhythmias are atrial fibrillation and flutter (AFF), for which treatment is not well defined. Recent studies have focused on prophylactically treating patients in an attempt to reduce postoperative AFF. Several studies have shown(More)
OBJECTIVES This prospective, randomized, double-blind, placebo-controlled study compared the efficacy and safety of amiodarone and sotalol in the prevention of atrial fibrillation (AF) following open heart surgery. BACKGROUND The incidence of supraventricular arrhythmias following open heart surgery ranges from 20% to 40%, with AF being the most common.(More)
The importance of the adrenal hormones in the lipogenic responses to meal-feeding or starvation-refeeding was studied. In experiment 1, intact or adrenalectomized (ADX) rats were either ad libitum-fed or meal-fed a 65% glucose diet for 21 days or until moribund (ADX rats only). Serum glucose and electrolytes (Ca++, Mg++, Na+, K+), hepatic glycogen and(More)
Intact and adrenalectomized (ADX) rats were starved for 48 hours and refed a 65% glucose diet for 48 hours. Isotonic saline or 8 azaguanine (8AZ) and/or glucocorticoid was administered to the animals during the refeeding period. The typical enzyme overshoot response to refeeding was observed in the intact rats and in the ADX rats given hormone replacement.(More)
STUDY OBJECTIVE To evaluate 24-hour blood pressure control and frequency of adverse effects in patients with mild to moderate hypertension switched from nifedipine gastrointestinal therapeutic system (Nif-GITS) to nifedipine coat core (Nif-CC). DESIGN Open-label, prospective, switch study SETTING University-affiliated outpatient cardiology clinic. (More)
DAN1EL E. HILLEMAN, Phann.D., is Professor and Chail; Department of Pharmacy Practice, Creighton Universily School of Pharmacy, Omalw, NE; MARK WOODRUFF, M.D, and M.JEFFREY HOLMBERG, M.D., Ph.D, arc Assistant Profcssors of Medicine at Creighton Universily School of Medicine. RICHARD L WURDEMAN, Phw'm.D., is Assistant Professor of Medicine at Creighton(More)
OBJECTIVE To report the occurrence of a novel group of adverse effects associated with initiation and rechallenge of orlistat. CASE SUMMARY A 42-year-old white woman developed symptoms of constipation, polyuria, polydipsia, and increased lower-leg edema after 2 weeks of treatment with orlistat 120 mg 3 times daily. The drug was discontinued for 4 days and(More)