Learn More
This paper applies and evaluates an automatic mutual information-based registration algorithm across a broad spectrum of multimodal volume data sets. The algorithm requires little or no pre-processing, minimal user input and easily implements either affine, i.e. linear or thin-plate spline (TPS) warped registrations. We have evaluated the algorithm in(More)
UNLABELLED The supraclavicular region is a common site for lymph node metastases. A commonly reported type of nonmalignant (18)F-FDG uptake on PET imaging in the supraclavicular region is "muscle uptake" purportedly due to muscle contraction in tense patients during the (18)F-FDG uptake phase. PET/CT offers the unique opportunity to correlate PET findings(More)
The authors have extended point-based registration to include simultaneous registration of points, lines, and planes, to permit accurate and easily implemented three-dimensional (3-D) registration of multimodal data sets for fusion of clinical anatomic and functional imaging modalities. Constructive geometry is used to define user-identified features where(More)
UNLABELLED This study evaluated the effect of various beta-adrenergic agonists on (18)F-FDG uptake in brown adipose tissue (BAT) in rats using ex vivo biodistribution studies. METHODS Caffeine (10 mg/kg of body weight, n = 4), ephedrine (5 mg/kg of body weight, n = 4), nicotine (0.8 mg/kg of body weight, n = 9), or a mixture of nicotine and ephedrine (0.8(More)
INTRODUCTION We studied the contribution of interictal FDG-PET ([18 F] fluorodeoxyglucose-positron emission tomography) in epileptic focus identification in temporal lobe epilepsy patients with positive, equivocal and negative magnetic resonance imaging (MRI). METHODS Ninety-eight patients who underwent surgical treatment for drug resistant temporal lobe(More)
Advances in technology have allowed extremely precise control of radiation dose delivery and localization within a patient. The ability to confidently delineate target tumor boundaries, however, has lagged behind. (18)F-FDG PET/CT, with its ability to distinguish metabolically active disease from normal tissue, may provide a partial solution to this(More)
UNLABELLED To investigate the contribution of various tumor components to tumor [3H]FDG uptake, the size of proliferative cell and macrophage populations and the extent of necrosis, inflammatory infiltration and granulation tissue formation were evaluated in syngeneic rat mammary cancers (RMC) grown in immunocompetent rats, an animal tumor model that(More)
UNLABELLED Estimation of tumor proliferative activity is important for the optimal management of head and neck cancer. Noninvasive metabolic imaging with PET may complement currently used cytopathologic methods to study tumor proliferation. METHODS Fluorodeoxyglucose (FDG) and L-methionine (MET) were studied for their potential to assess in vitro the(More)
BACKGROUND AND AIM In a combined positron emission tomography (PET) and computed tomography (CT) system, the CT images can be used for attenuation correction as well as for image fusion. However, quantitative and qualitative differences have been reported between CT based attenuation corrected PET and conventional transmission scan corrected PET images. The(More)
UNLABELLED This article assesses the resulting accuracies of 2 registration methods using the same multimodal mutual information registration algorithm. In the indirect, fusion method, the CT dataset is warped onto the PET transmission scan, and then the patient's attenuation-corrected emission dataset is substituted for the transmission dataset. In the(More)