Richard L. Schmoyer

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Lung cancer continues to be the leading cause of cancer death in developed countries. With smoking the major etiological factor for lung cancer, there is a great need for the development of chemopreventive treatments that inhibit the progression of initiated cells and premalignant lesions into overt lung cancer in smokers who quit. Although the major focus(More)
Urethane, a chemical that has given varied results in mutagenesis assays, was tested in the mouse specific-locus test, and its effect on germ-cell survival was explored. Altogether 32,828 offspring were observed from successive weekly matings of males exposed to the maximum tolerated i.p. dose of 1750 mg urethane/kg. The combined data rule out (at the 5%(More)
We have previously shown that administration of the antioxidant butylated hydroxytoluene (BHT) to mice produces lung damage that can be markedly potentiated by hyperoxia resulting in pulmonary fibrosis. In the present studies using this model, we show that: (1) in animals treated with BHT-O2, prednisolone given for 12 successive days does prevent excessive(More)
Note: Abstract + Text + References = 6529 words (with 1 table + 2 figures also attached, equivalent to 7329 words) ABSTRACT This paper details development of a system for using Nationwide Personal Transportation Survey (NPTS) data to estimate regional or local travel behavior vehicle and person trips and miles of travel. This system can be used by state or(More)
Two-wheeler vehicles in Delhi, India--roughly 70% of the total vehicle fleet--are responsible for a significant portion of the city's vehicle emissions and petroleum consumption. An inspection and maintenance (I/M) program that ensures vehicle emission control systems are well maintained can complement other emission reduction strategies. This paper(More)
Twenty-two derivatives of naphthalene were assayed under an acute static regime with biological activity being monitored as population growth of Tetrahymena pyriformis. Activity varied over one log unit. Substituent constant structure-activity analyses revealed the model, log BR = 0.282Ha + 0.352 pi + 0.692F + 0.3341Xvsub - 0.326R + 0.027, to be best and to(More)
Sprague-Dawley rats were exposed to aerosolized diesel fuel (ADF) to determine the potential health effects in military troops during exposure to this visual obscurrant. Acute range finding studies were performed to estimate exposure conditions at which minimal (less than 1%) mortality would occur. This information was used in the design of a repeated(More)
Baseline and mitomycin C (MMC)-induced sister chromatid exchanges (SCEs) in two human tumor cell lines (a colon tumor and a melanoma) and in a normal fibroblast cell line were analyzed and compared. The tumor cells showed numerical and structural chromosomal abnormalities. Their baseline SCE rate was slightly, but not significantly, higher than that of the(More)
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