Richard L Prince

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BACKGROUND Increased dietary calcium intake has been proposed as a population-based public health intervention to prevent osteoporotic fractures. We have examined whether calcium supplementation decreases clinical fracture risk in elderly women and its mechanism of action. METHODS Five-year, double-blind, placebo-controlled study of 1460 women recruited(More)
Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral density (BMD) is a major predisposing factor to fracture and is known to be highly heritable. Site-, gender-, and age-specific genetic effects on BMD are thought to be significant, but have largely not been considered in the design of genome-wide association(More)
UNLABELLED Using a moderate-sized cohort selected with extreme BMD (n = 344; absolute value BMD, 1.5-4.0), significant association of several members of the Wnt signaling pathway with bone densitometry measures was shown. This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes. (More)
UNLABELLED A follow-up in 1262 women was conducted after the discontinuation of teriparatide. The hazard ratio for combined teriparatide group (20 and 40 microg) for the 50-month period after baseline was 0.57 (p = 0.002), suggesting a sustained effect in reducing the risk of nonvertebral fragility fracture. INTRODUCTION Treatment with teriparatide(More)
OBJECTIVES To examine whether fear of falling is a probable cause of reduced recreational physical activity levels in healthy older women. DESIGN Cross-sectional analysis of baseline data from a longitudinal study. PARTICIPANTS One thousand five hundred older, ambulatory women (aged 70-85), selected at random from the electoral roll. MEASUREMENTS(More)
OBJECTIVES To determine longitudinal predictors of incident and persistent fear of falling (FOF) in older women. DESIGN Longitudinal study. SETTING Clinical research center based at a university hospital. PARTICIPANTS One thousand two hundred eighty-two community-dwelling women aged 70 to 85. MEASUREMENTS FOF at baseline and after 3 years of(More)
Hip structural analysis (HSA) is a technique for extracting strength-related structural dimensions of bone cross-sections from two-dimensional hip scan images acquired by dual energy X-ray absorptiometry (DXA) scanners. Heretofore the precision of the method has not been thoroughly tested in the clinical setting. Using paired scans from two large clinical(More)
We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide(More)
BACKGROUND Impaired hip structure assessed by dual-energy X-ray absorptiometry (DXA) areal bone mineral density (aBMD) is an independent predictor for osteoporotic hip fracture. Some studies suggest that tea intake may protect against bone loss. OBJECTIVE Using both cross-sectional and longitudinal study designs, we examined the relation of tea(More)
OBJECTIVE To assess the effects of androgen deprivation therapy (ADT) on whole-body and regional muscle, fat and bone mass in men with prostate cancer without metastatic bone disease. PATIENTS AND METHODS Seventy-two men aged 44-88 years underwent spine, hip and whole-body dual-energy X-ray absorptiometry scans at baseline and after 36 weeks of ADT. The(More)