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Neuroinflammation: friend and foe for ischemic stroke
TLDR
How neuroinflammation has both beneficial as well as detrimental roles and recent therapeutic strategies to combat pathological responses are discussed and the time-dependent role of inflammatory factors could help in developing new diagnostic, prognostic, and therapeutic neuroprotective strategies for post-stroke inflammation. Expand
Production of Extracellular Pectinase by Bacillus Cereus Isolated From Market Solid Waste
Pectin is a major component of primary cell wall of all land plants and encompasses a range of galacturonic acid rich polysaccharides. Pectinase or pectinolytic enzyme, hydrolyzes pectic substance,Expand
Neuroprotective Effect of CNB-001, a Novel Pyrazole Derivative of Curcumin on Biochemical and Apoptotic Markers Against Rotenone-Induced SK-N-SH Cellular Model of Parkinson’s Disease
TLDR
The results suggest that CNB-001 protects neuronal cell against toxicity through antioxidant and antiapoptotic properties through its action on mitochondria and can be further developed as a promising drug for treatment of PD. Expand
Taxifolin mitigates oxidative DNA damage in vitro and protects zebrafish (Danio rerio) embryos against cadmium toxicity.
TLDR
The results concluded that TAX could act as a potent redox scavenger against oxidative DNA damage and also functions as a crucial suppressor of Cd toxicity in zebrafish embryos. Expand
Taxifolin curbs NF-κB-mediated Wnt/β-catenin signaling via up-regulating Nrf2 pathway in experimental colon carcinogenesis.
TLDR
Results of the hypothesis shown that TAX is an effective chemopreventive agent capable of modulating inflammatory, Wnt and antioxidant response pathway proteins in tumor microenvironment which explicating its anticancer property. Expand
Outdoor Ambient Air Pollution and Neurodegenerative Diseases: the Neuroinflammation Hypothesis
TLDR
Multiple direct and indirect pathways in response to air pollution exposure likely interact in concert to exert CNS effects. Expand
CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson's Disease
TLDR
Investigation of the neuroprotective property of CNB-001 in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine rodent model of PD supports its strong therapeutic potential for treatment of PD. Expand
Escin, a Novel Triterpene, Mitigates Chronic MPTP/p-Induced Dopaminergic Toxicity by Attenuating Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis
TLDR
It is speculated that escin might be a promising candidate for the prevention of mitochondrial dysfunction-induced apoptosis in neurodegenerative disorders such as PD. Expand
CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice.
TLDR
Results demonstrate that CNB-001 is neuroprotective through its anti-inflammatory and anti-apoptotic properties and has potential to be further developed as a therapeutic candidate for treatment of PD. Expand
The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammation in sodium valproate induced autism in mice.
TLDR
This is the first in vivo demonstration of the effectiveness of a potent dual-active H3R antagonist and AChE inhibitor against autistic-like repetitive compulsive behaviors and neuroinflammation, and provides evidence for the role of such compounds in treating ASD. Expand
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