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Comparative protein structure prediction is limited mostly by the errors in alignment and loop modeling. We describe here a new automated modeling technique that significantly improves the accuracy of loop predictions in protein structures. The positions of all nonhydrogen atoms of the loop are optimized in a fixed environment with respect to a pseudo(More)
B lymphocyte stimulator (BLyS) is a newly identified monocyte-specific TNF family cytokine. It has been implicated in the development of autoimmunity, and functions as a potent costimulator with antiimmunoglobulin M in B cell proliferation in vitro. Here we demonstrate that BLyS prominently enhances the humoral responses to both T cell-independent and T(More)
BACKGROUND As the largest single lymphatic organ in the human body, the spleen is responsible for central immunological and haematological tasks. Therefore, the spleen can be subject to a wide range of pathologic disorders. Computed tomography (CT) represents the most widely applied cross-sectional abdominal imaging technique and is considered the imaging(More)
BACKGROUND Texture analysis is a promising method of analyzing imaging data to potentially enhance diagnostic capability. This approach involves automated measurement of pixel intensity variation that may offer further insight into disease progression than do standard imaging techniques alone. We postulated that postoperative liver insufficiency, a major(More)
RATIONALE AND OBJECTIVES Motion artifacts are a significant source of error in the acquisition and quantification of parameters from multi-b-value diffusion-weighted imaging (DWI). The objective of this article is to present a reliable method to reduce motion-related artifacts during free-breathing at higher b-values when signal levels are low. MATERIALS(More)
PURPOSE Apparent diffusion coefficient (ADC), derived from diffusion-weighted magnetic resonance images (DW-MRI), measures the motion of water molecules in vivo and can be used to quantify tumor response to therapy. The accurate measurement of ADC can be adversely affected by organ motion and imaging artifacts. In this paper, the authors' goal was to(More)
The increasing incidence and high morbidity and mortality of hepatocellular carcinoma (HCC) have inspired the creation of the Liver Imaging Reporting and Data System (LI-RADS). LI-RADS aims to reduce variability in exam interpretation, improve communication, facilitate clinical therapeutic decisions, reduce omission of pertinent information, and facilitate(More)
PURPOSE To investigate associations between imaging features of cholangiocarcinoma by visual assessment and texture analysis, which quantifies heterogeneity in tumor enhancement patterns, with molecular profiles based on hypoxia markers. METHODS The institutional review board approved this HIPAA-compliant retrospective study of CT images of intrahepatic(More)
Texture analysis of preoperative CT images of the liver is undertaken in this study. Standard texture features were extracted from portal-venous phase contrast-enhanced CT scans of 36 patients prior to major hepatic resection and correlated to postoperative liver failure. Differences between patients with and without postoperative liver failure were(More)