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The aim of the present study was to examine impairment of implicit learning in Parkinson's disease (PD) by means of a meta-analysis of studies that used the serial reaction time (SRT) task. The authors performed a systematic review and meta-analysis of published journal articles (1987-2005) that used the SRT task with patients with PD. The principal outcome(More)
Establishing valid and reliable measures for use with patients with disorders of consciousness (DOC) following profound brain injury is challenging due to a number of factors including the complex presentation of such patients and assessor variability. The auditory modality has been demonstrated to have greater sensitivity for detecting awareness in DOC(More)
Several studies have reported high rates of depression in multiple sclerosis (MS) with a lifetime prevalence of approximately 50% and an annual prevalence of 20% not uncommon. Concern about the potential of new drug treatments to exacerbate or precipitate depression in MS has led to increased interest in the relation between MS and depression. This review(More)
INTRODUCTION Frith's (1992) neuropsychological theory of schizophrenia posits a number of fundamental cognitive impairments underpinning the characteristic symptoms of this disorder. One of these is an impairment in the ability to correctly interpret and predict the mental states of other people, so-called theory of mind (ToM). There is already a(More)
Thirteen nondemented patients with Parkinson's disease (PD) were compared with age-matched controls on two standard tests of implicit learning. A verbal version of the Serial Reaction Time (SRT) task was used to assess sequence learning and an artificial grammar (AG) task assessed perceptual learning. It was predicted that PD patients would show implicit(More)
Cognition in schizophrenia seems to be characterized by impaired performance on most tests of explicit or declarative learning contrasting with relatively intact performance on most tests of implicit or procedural learning. At the same time there have been conflicting results for studies that have used the Serial Reaction Time (SRT) task to examine implicit(More)
INTRODUCTION Theory-of-mind (ToM) refers to the ability to understand and predict the behaviour of others based on their mental states. Research from brain imaging and lesion studies indicate that the frontal lobes are both involved and necessary to understand mental states. METHODS A total of 13 people with Parkinson's disease were compared with 11(More)
Evidence suggests that patients suffering from Parkinson's Disease (PD) demonstrate less sequence learning in the serial reaction time (SRT) task devised by Nissen and Bullemer (1987). One of the problems with this task is that it is motor intensive and, given the motor difficulties which characterize Parkinson's disease (e.g., tremor, impaired facility of(More)
INTRODUCTION There is already a substantial body of evidence supporting Frith's (1992) theory that theory of mind (ToM) is impaired in people with schizophrenia. However, a specific relationship between impaired ToM and paranoid delusions, while intuitively reasonable, has only been demonstrated in two studies to date. METHODS A total of 25 participants(More)
The purpose of the present study was to assess the effect of a high-gluten diet against a gluten-free diet on learning stimulus-response relationships in rats. In the first phase of training rats learned to associate a stimulus light with responding on a particular response lever. In the second phase, the same rats were exposed to new, but redundant stimuli(More)