Richard John Sears

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OBJECTIVES Partial gastrectomy patients with anatomic alterations to the pylorus and acid secretion are excellent models for studying the controversial role of duodenogastric reflux in producing esophageal symptoms and esophagitis. METHODS We studied 13 partial gastrectomy patients who had recent upper gastrointestinal endoscopies and chronic(More)
The incidence of pancreatic adenocarcinomas (PA) is increased in the setting of chronic pancreatitis. Distinguishing chronic pancreatitis from pancreatic adenocarcinomas is often difficult, and is based on routine brush cytological specimens provided during endoscopic retrograde cholangiopancreatography (ERCP). Reactive epithelial changes in chronic(More)
BACKGROUND Routine brush cytology is relatively insensitive for the diagnosis of biliary and pancreatic malignancy. Sensitivity can be improved by measuring DNA and proliferation. The goal of this study was to assess the discriminatory capacity of image cytometry using pancreaticobiliary brush cytology specimens obtained during endoscopic retrograde(More)
A series of experiments were conducted to determine what factors control responding to the first element of a two-element serial compound in rabbit eyelid conditioning. An examination of response topography indicated that the eye-blink CR is rigidly timed to occur when the US is expected. This response-system characteristic prevents the occurrence of a CR(More)
The effect of octreotide on sphincter of Oddimotility was investigated in six liver transplantpatients, employing percutaneous (through the T-tubetract) manometry. Continuous and simultaneous sphincter of Oddi and duodenal motor activities wererecorded before and for 60 min after the administrationof octreotide (100 μg subcutaneously) and after theinjection(More)
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