Richard J. McCormick

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Maternal obesity (MO) has harmful effects on both fetal development and subsequent offspring health. We previously demonstrated that MO enhances collagen accumulation in fetal skeletal muscle, but its impact on mature offspring muscle collagen accumulation is unknown. Ewes were fed either a control diet (Con, fed 100% of NRC nutrient recommendations) or(More)
The hydroxypyridinium (HP) crosslink is the predominant non-reducible collagen crosslink in heart. HP concentration in left ventricle (LV) increases progressively throughout life, and this increase is thought to reflect the slower turnover of collagenous proteins seen with aging, allowing mature extracellular matrix (ECM) collagen to crosslink more heavily.(More)
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