Richard J. Griffiths

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Leukotrienes are potent inflammatory mediators synthesized from arachidonic acid (AA) predominately by cells of myeloid origin. The synthesis of these lipids is believed to be dependent not only on the expression of the enzyme 5-lipoxygenase (5-LO), which catalyzes the first steps in the synthesis of leukotrienes, but also on expression of a nuclear(More)
Collagen-induced arthritis in the DBA/1 mouse is an experimental model of human rheumatoid arthritis. To examine the role of leukotrienes in the pathogenesis of this disease, we have developed embryonic stem (ES) cells from this mouse strain. Here, we report that DBA/1 mice made deficient in 5-lipoxygenase-activating protein (FLAP) by gene targeting in ES(More)
The effect of the selective alpha 2-adrenoceptor agonists, naphazoline and xylazine, was studied on the field stimulated bisected rat vas deferens. Xylazine inhibited the twitch response to field stimulation in both the prostatic (ID50 = 0.10 microM) and epididymal (ID50 = 0.08 microM) halves of the rat vas deferens. This effect was antagonized by yohimbine(More)
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