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Planning a response to an outbreak of a pandemic strain of influenza is a high public health priority. Three research groups using different individual-based, stochastic simulation models have examined the consequences of intervention strategies chosen in consultation with U.S. public health workers. The first goal is to simulate the effectiveness of a set(More)
We describe "first principles" based methods for developing synthetic urban and national scale social contact networks. Unlike simple random graph techniques, these methods use real world data sources and combine them with behavioral and social theories to synthesize networks. We develop a synthetic population for the United States modeling every individual(More)
Methods are needed to assist with automating three-color flow cytometric immunophenotyping of bone marrow from leukemia patients. Described is a method in which a normal bone marrow data set is used as a template against which to compare leukemic bone marrow data sets. This template is obtained using techniques of cluster analysis and cluster editing.(More)
—In this paper, we develop a microscopic, agent-based simulation tool, called SIGMA-SPECTRUM to study the dynamics of the primary wireless spectrum market. A detailed, synthetic demand model, is used to produce disaggregated spectrum demand profiles that vary spatially and temporally for each individual in the population. We implement a truthful and(More)
strongly supports academic freedom and a researcher's right to publish; as an institution, however, the Laboratory does not endorse the viewpoint of a publication or guarantee its technical correctness. Abstract The TRANSIMS (TRansportation ANalysis and SIMulation System) project at the Los Alamos National Laboratory attempts to model all aspects of human(More)
Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents the final step of a project aimed at using a combination of simulation, classification, statistical and optimization techniques to forecast(More)