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We describe "first principles" based methods for developing synthetic urban and national scale social contact networks. Unlike simple random graph techniques, these methods use real world data sources and combine them with behavioral and social theories to synthesize networks. We develop a synthetic population for the United States modeling every individual(More)
strongly supports academic freedom and a researcher's right to publish; as an institution, however, the Laboratory does not endorse the viewpoint of a publication or guarantee its technical correctness. Abstract The TRANSIMS (TRansportation ANalysis and SIMulation System) project at the Los Alamos National Laboratory attempts to model all aspects of human(More)
—In this paper, we develop a microscopic, agent-based simulation tool, called SIGMA-SPECTRUM to study the dynamics of the primary wireless spectrum market. A detailed, synthetic demand model, is used to produce disaggregated spectrum demand profiles that vary spatially and temporally for each individual in the population. We implement a truthful and(More)
Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents the final step of a project aimed at using a combination of simulation, classification, statistical and optimization techniques to forecast(More)
Individual-based epidemiology models are increasingly used in the study of influenza epidemics. Several studies on influenza dynamics and evaluation of intervention measures have used the same incubation and infectious period distribution parameters based on the natural history of influenza. A sensitivity analysis evaluating the influence of slight changes(More)
We describe ISIS, a high-performance-computing-based application to support computational epidemiology of infectious diseases. ISIS has been developed over the last seven years in close coordination with public health and policy experts. It has been used in a number of important federal planning and response exercises. ISIS grew out of years of experience(More)