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Acute and chronic pulmonary and cardiac diseases often have a high mortality rate, and can be a source of significant suffering. Palliative care, as described by the Institute of Medicine, "seeks to prevent, relieve, reduce or soothe the symptoms of disease or disorder without effecting a cure... Palliative care in this broad sense is not restricted to(More)
STUDY OBJECTIVES To determine whether sedation with propofol would lead to shorter times to tracheal extubation and ICU length of stay than sedation with midazolam. DESIGN Multicenter, randomized, open label. SETTING Four academic tertiary-care ICUs in Canada. PATIENTS Critically ill patients requiring continuous sedation while receiving mechanical(More)
vessels and of the midbrain and pons. There was tentorial herniation, greater on the right. There was no evidence of previous cell loss or of inflammatory reaction. Comment Water intoxication causes hyponatraemia, which is responsible for the neurological dysfunction by causing intracellular overhydration. Symptoms may occur if the serum sodium(More)
Effects of alfentanil, preceded by lorazepam, on suppression of haemodynamic and somatic responses to noxious stimuli was studied in patients undergoing CABG. Plasma concentration of alfentanil, somatic and haemodynamic responses were measured at loss of consciousness, tracheal intubation, sternotomy and during multiple application of electrocoagulation.(More)
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