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Delivery of oxygen to tissue is an essential function of the circulatory system. The distance that oxygen can diffuse into oxygen-consuming tissue is small, and so tissue oxygenation is critically dependent on the spatial arrangement of microvessels in tissue. Theoretical methods have been developed to simulate the spatial distribution of oxygen levels in(More)
Formation of functionally adequate vascular networks by angiogenesis presents a problem in biological patterning. Generated without predetermined spatial patterns, networks must develop hierarchical tree-like structures for efficient convective transport over large distances, combined with dense space-filling meshes for short diffusion distances to every(More)
The kcc(DHS1) allele of kazachoc (kcc) was identified as a seizure-enhancer mutation exacerbating the bang-sensitive (BS) paralytic behavioral phenotypes of several seizure-sensitive Drosophila mutants. On their own, young kcc(DHS1) flies also display seizure-like behavior and demonstrate a reduced threshold for seizures induced by electroconvulsive shock.(More)
BACKGROUND Because of the inefficient vasculature of solid tumors, anticancer drugs must penetrate relatively long distances through the extravascular compartment. The requirement for such diffusion may limit their activity, especially that of hypoxia-targeted drugs. We tested whether a three-dimensional pharmacokinetic/pharmacodynamic (PK/PD) model based(More)
PURPOSE To develop a theoretical model for oxygen delivery to tumors, and to use the model to simulate the effects of changing the affinity of hemoglobin for oxygen on tumor oxygenation. METHODS AND MATERIALS Hemoglobin affinity is expressed in terms of P(50), the partial pressure of oxygen (Po(2)) at half saturation. Effects of changing P(50) on arterial(More)
PURPOSE To simulate effects of reduced oxygen consumption combined with hyperoxic gas breathing on tumor oxygenation, and to test for synergistic effects. METHODS AND MATERIALS Diffusive oxygen transport was simulated for a small region of tumor containing a three-dimensional network of microvessels whose geometry was derived from in vivo observations.(More)
SnowFort, an open source wireless sensor network (WSN) for data analytics, is proposed for monitoring infrastructure and environment. The wireless sensing unit is optimized to be low power for extremely long-term deployments. Several features, such as data compression and online reconfiguration, are introduced to further reduce power consumption. A low(More)
OBJECTIVES Duplication of the inferior vena cava (IVC) complicates interventional procedures. This case report aims to shed light on this unusual anomaly and the preoperative considerations necessary when treatment of venous thromboembolism is undertaken. METHODS An IRB approved case report of a 58 year old woman presented emergently with right lower(More)
INTRODUCTION A large body of experimental evidence shows that the endothelial surfaces of microvessels are lined with a relatively thick layer of macromolecules, which has a substantial impact on the mechanics and hemodynamics of blood flow [1]. This layer, known as the glycocalyx or endothelial surface layer (ESL), has been estimated to be from 0.3 μm to(More)
In the current study, we investigated the mechanism by which protein kinase C (PKC) regulates the expression of b1-adrenergic receptor (b1AR) mRNA in rat C6 glioma cells. Exposure of the cells to 4b-phorbol-12-myristate-13-acetate (PMA), an activator PKC, resulted in a down-regulation of both b1AR binding sites and mRNA levels in a timeand(More)