Richard Hosking

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Expression of the neuropeptide galanin is markedly upregulated within the adult dorsal root ganglion (DRG) after peripheral nerve injury. We demonstrated previously that the rate of peripheral nerve regeneration is reduced in galanin knock-out mice, with similar deficits observed in neurite outgrowth from cultured mutant DRG neurons. Here, we show that the(More)
The chimeric peptide M35 (galanin(1-3)-bradykinin(2-9)amide) is a high-affinity galanin receptor ligand which acts as a galanin receptor antagonist in many experimental models such as the flexor reflex and chronic constriction injury in rat. However, more recently there have been conflicting reports that M35 may act as a galanin receptor agonist in certain(More)
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As computationally-enabled approaches to research become more prevalent across all disciplines, the gap between what students and researchers know, and what they need to know to leverage these new approaches, widens. By now it is a huge gulf, with cyberinfrastructures and computer scientists on one side and most of our potential users and collaborators on(More)
In this paper we explore two questions that we feel are important to investigate further if geographic information observatories are to be fruitful research endeavor in GIScience. The first question is simply 'what is a geographic information observatory (and what is it not)?' and the second question is 'what use is a geographic information obser-vatory?'.(More)
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