Richard Hesketh

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Electrification in developed countries has progressively increased the mean level of extremely low-frequency electromagnetic fields (ELF-EMFs) to which populations are exposed; these humanmade fields are substantially above the naturally occurring ambient electric and magnetic fields of approximately 10(-4) Vm(-1) and approximately 10(-13) T, respectively.(More)
Plasmodium falciparum genotyping has recently undergone a revolution, and genome-wide genotype datasets are now being collected for large numbers of parasite isolates. By contrast, phenotyping technologies have lagged behind, with few high throughput phenotyping platforms available. Invasion of human erythrocytes by Plasmodium falciparum is a phenotype of(More)
Combretastatin-A4 phosphate (cis-CA-4) is a tubulin-binding agent currently undergoing clinical trials as an anti-tumour drug. We have investigated whether CA-4 functions as a tumour-specific anti-vascular agent using the hyperplastic thyroid as a novel in vivo model of neovascularization. CA-4 elicited pathological changes in normal tissue, manifested as(More)
The Dirt 1 user interface builder provides an interactive editor for the rapid-prototyping and iterative development of user interfaces using the Xt Toolkit under the X Window System 2. User interfaces are created interactively by the direct manipulation of user interface objects (also called Widgets) such as push buttons, menus and scroll bars. Each object(More)
SUMMARY Modern UNIX-based graphical workstations still lack really graphical interfaces. Yet recreating existing UNIX tools with graphical interfaces may prove to be a prohibitive task. This paper describes the design and implementation of a set of tools that make the task of providing a graphical UNIX user interface easier. The main tool, called Perly,(More)
PURPOSE Metabolic imaging with hyperpolarized 13 C-labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses that can be used. We describe here a single-shot(More)
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