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ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including glial cells in the central nervous system. Activation of P2X(7) receptors leads to rapid changes in intracellular calcium concentrations, release of the proinflammatory cytokine interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cytolytic plasma(More)
How RNA-binding proteins recognize specific sets of target mRNAs remains poorly understood because current approaches depend primarily on sequence information. In this study, we demonstrate that specific recognition of messenger RNAs (mRNAs) by RNA-binding proteins requires the correct spatial positioning of these sequences. We characterized both the(More)
JEL classification: L25 R11 R38 Keywords: R&D tax credit Northern Ireland Productivity a b s t r a c t This paper studies the impact of R&D spending on output as well as forecasting the impact of a regionally enhanced R&D tax credit on the 'user cost' (or price) of R&D expenditure and subsequently the demand for R&D. The example we use of a 'disadvantaged'(More)
BACKGROUND Following the amputation of a limb, newts and salamanders have the capability to regenerate the lost tissues via a complex process that takes place at the site of injury. Initially these cells undergo dedifferentiation to a state competent to regenerate the missing limb structures. Crucially, dedifferentiated cells have memory of their level of(More)
Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-582941 was found to exhibit high-affinity(More)
This article describes a web-based computer-assisted tool for diagnosing progress in international negotiation. Following a discussion of the need for such a tool, we provide the research sources for its development, present the model on which it is based, describe how it works, and present the results of attempts to validate its diagnoses with case(More)
The MUS81-EME1 endonuclease maintains metazoan genomic integrity by cleaving branched DNA structures that arise during the resolution of recombination intermediates. In humans, MUS81 also forms a poorly characterized complex with EME2. Here, we identify and determine the structure of a winged helix (WH) domain from human MUS81, which binds DNA. WH domain(More)
COS-7 cells were cotransfected as indicated with empty vector (Control), vectors encoding wild-type Rac2 (250 ng per well), ΔN-Vav1 (500 ng per well), and/or wild-type or mutant PLCγ isozymes. The amounts of vectors encoding the PLCγ isozymes were adjusted according to their basal activities shown in the left panel of Fig. ng per well. The total amount of(More)