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BACKGROUND In the Medical Research Council (MRC) COIN trial, the epidermal growth factor receptor (EGFR)-targeted antibody cetuximab was added to standard chemotherapy in first-line treatment of advanced colorectal cancer with the aim of assessing effect on overall survival. METHODS In this randomised controlled trial, patients who were fit for but had(More)
PURPOSE The purpose of this study was to examine in listeners with normal hearing and listeners with sensorineural hearing loss the within- and between-group differences obtained with 4 commonly available speech-in-noise protocols. METHOD Recognition performances by 24 listeners with normal hearing and 72 listeners with sensorineural hearing loss were(More)
A one-, two-, and three-pair dichotic digit test was administered to 180 subjects (20-79 years) with varying degrees of hearing sensitivity. The test was carried out under free- and directed-recall response conditions. The results indicated that recognition performance decreased as a function of increasing age. Statistical analysis using analysis of(More)
Oxaliplatin, an effective cytotoxic treatment in combination with 5-fluorouracil for colorectal cancer, is associated with sensory, motor and autonomic neurotoxicity. Motor symptoms include hyperexcitability while autonomic effects include urinary retention, but the cause of these side-effects is unknown. We examined the effects on motor nerve function in(More)
Two descriptive experiments were performed on a version of the Northwestern University Auditory Test No. 6 (NU No. 6) recorded by a female speaker that is included on an audio compact disc recently produced by the Department of Veterans Affairs. In Experiment 1, normative psychometric functions for the female speaker version of the NU No. 6 materials were(More)
Dichotic listening was evaluated using monosyllabic word pairs that differed in lexical difficulty as defined by the Neighborhood Activation Model of spoken word recognition. Four combinations of lexically EASY and lexically HARD words were evaluated (same pair: EASY-EASY, HARD-HARD; or mixed pair: EASY-HARD, HARD-EASY) in young adult listeners with normal(More)
The equivalence was determined for the W-22 and NU No. 6 lists recorded with the same carrier phrase and by the same speaker (Auditec compact disc). For presentation, the lists were interleaved to form lists of 100 words. In Experiment 1, the materials were presented in quiet (0 to 30 dB HL) and in 60 dB SPL speech-spectrum noise (35 to 65 dB HL) at 5 dB(More)
Dichotic digit listening was made more difficult by interleaving one-, two-, three-, and four-pair digits within a test list in which the subjects did not know a priori the number of digit pairs presented on a given trial, thereby introducing listener uncertainty. Twenty right-handed (mean age = 26.8 years) and 20 left-handed adults (mean age = 24.0) with(More)
Four patients who preferred monaural as compared with binaural amplification were evaluated. For these patients, audiometric data, recognition performance on a dichotic digit task, and monaural and binaural hearing aid performance using four amplification strategies (National Acoustic Laboratories-Revised, a speech in noise algorithm, multiple-microphone(More)
PURPOSE Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have(More)