Richard H. Adrian

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1. Propagated action potentials of striated muscle are calculated using an equivalent circuit that represents the transverse tubular system as a radial cable of sixteen elements. The membrane of the transverse tubules is assumed to have activatable ionic currents similar to those in the fibre surface.2. The configuration of the after-potential and the(More)
1. The kinetics of mechanical activation were examined in muscle fibres of the frog's sartorius muscle, using a voltage clamp to control membrane potential, tetrodotoxin to eliminate electrical activity and microscopic observations to determine the mechanical threshold.2. The strength-duration curve was determined over a range of membrane potentials varying(More)
1. Membrane currents during step depolarizations were determined by a method in which three electrodes were inserted near the end of a fibre in the frog's sartorius muscle. The theoretical basis and limitations of the method are discussed.2. Measurements of the membrane capacity (C(M)) and resting resistance (R(M)) derived from the current during a step(More)
1. The transient current required to impose a step charge of potential has a complex time course especially in the region of internal potential between -50 and -40 mV. 2. Examination of non-linear transient current in this voltage range suggests two components of charge movement: (a) an initial more-or-less exponential movement, and (b) a slower component(More)
  • R H Adrian
  • Annual review of biophysics and bioengineering
  • 1976
This account of charge movement in striated muscle membrane must be regarded as essentially tentative. I have tried to present, within a simplified descriptive scheme, one way in which the present confusion of results can be resolved into a self-consistent account. But I am sure that as more complete and more accurate measurements are made, the deficiencies(More)
1. The membrane potential of isolated muscle fibres in solutions containing tetrodotoxin (TTX) was controlled with a two-electrode voltage clamp. The striation pattern in the region of the electrodes was observed microscopically.2. With square steps of depolarization of increasing magnitude, contraction occurs first in the myofibrils just beneath the(More)
1. Muscle fibres from myotonic goats respond to injected constant currents with a train of action potentials. If the number of action potentials in an evoked train exceeds 10-15, stopping the current does not stop the repetitive firing of action potentials.2. Normal muscle fibres (goat) in a chloride-free Ringer respond in the same way to constant(More)