Richard Graham

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1. Glomerular permeability was studied by ultrastructural cytochemistry, using as protein tracers two intravenously injected peroxidases of differing molecular weight. 2. Horseradish peroxidase (molecular weight 40,000) passed rapidly through the endothelial fenestrae, across the basement membrane, and through the epithelial slits into the urinary space.(More)
OBJECTIVES We sought to compare emergency coronary angiography with or without rescue percutaneous coronary intervention (PCI) with conservative treatment in patients with failed fibrinolysis complicating ST-segment elevation myocardial infarction (STEMI). BACKGROUND Most patients with STEMI receive fibrinolytic therapy and aspirin. The management of(More)
BACKGROUND Stentless aortic bioprostheses have been advocated as being superior to conventional bioprosthetic valves, with benefits including superior left ventricular mass regression and larger effective orifice area. Several high-quality randomized studies now exist on this topic, and we sought to summarize them by meta-analysis. METHODS The literature(More)
A 10-year-old girl was first seen at age 5 years with pneumonia and neutropenia. Since then, she has remained leukopenic, although manifesting a leukocytosis only when she has pulmonary infection. A rapid fall in her peripheral WBC count occurs with initiation of antibiotic therapy. Despite her neutropenia, marked myeloid hyperplasia is evident on marrow(More)
AIMS To investigate the mode of action of a blend of essential oil compounds on the colonization of starch-rich substrates by rumen bacteria. METHODS AND RESULTS Starch-rich substrates were incubated, in nylon bags, in the rumen of sheep organized in a 4 x 4 latin square design and receiving a 60:40 silage : concentrate diet. The concentrate was either(More)
PURPOSE Disinfecting agents found in current multipurpose solutions (MPS) may produce low-grade ocular surface insults. This study investigates the potential for carboxymethylcellulose (CMC) to chemically complex residual disinfectants in situ. METHODS The chemical availability of the MPS disinfectant polyhexamethylene biguanide (PHMB) was examined using(More)
The interaction of lymphoid cells with vascular endothelium was studied during the development of immunologic synovitis in response to repeated intraarticular injections of a heterologous protein antigen. Lymphoid cells emigrated in venules and small veins, both by penetrating the endothelial cytoplasm and by traversing intercellular junctions. Frequent(More)
An O3 dosimetry model is used to simulate the local absorption of O3 in the lower respiratory tract of rats and guinea pigs. The model takes into account lower respiratory tract anatomy, transport in the lumen and air spaces, and transport and chemical reactions in the mucous and surfactant layers and in the underlying tissue and capillaries. For each(More)