Richard F Begley

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The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The apparatus uses a novel fibre-optic(More)
DNA-programmed chemistry (DPC) is a novel technology for synthesis of a wide variety of organic compounds at nanomolar concentrations under physiologic conditions (1 ). Annealing of small molecule-oligonucleotide precursors to DNA templates, each with an attached chemical moiety, can generate high amounts of effective molarities of these reactants. This(More)
An attractive source for spaceborne laser communications is the directly modulated single-mode GaAs/GaAlAs injection laser. GaAlAs lasers, however, show low power per diode and wide beam divergence. A simple optical concept for a laser beam combiner overcomes diode laser limitations: an array of closely packed parallel collimated laser beams can be handled(More)
The (12)CF(4) molecule has been made to lase at various wavelengths in the 16-microm v(4) + V(2) ? V(2) band by pumping in the 9-microm 0 ? V(2) + V(4) band with (12)C(16)O(2) lines. The strongest reported (12)CF(4) laser line occurs at 615.06 cm(-1) and is pumped by 9R12 [9-microm band, R(12) line]. We have measured, by two techniques, the absorption of(More)
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