Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial
- S. Khan, R. Chatterton, R. Bergan
- MedicineCancer Prevention Research
- 1 February 2012
A 6-month intervention of mixed soy isoflavones in healthy, high-risk adult Western women did not reduce breast epithelial proliferation, suggesting a lack of efficacy for breast cancer prevention and a possible adverse effect in premenopausal women.
Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development
- Rajshekhar R. Giraddi, C. Chung, B. Spike
- BiologyCell Reports
- 7 August 2018
Multiple Molecular Subtypes of Triple-Negative Breast Cancer Critically Rely on Androgen Receptor and Respond to Enzalutamide In Vivo
- Valerie N. Barton, Nicholas C. D’Amato, J. Richer
- Biology, ChemistryMolecular Cancer Therapeutics
- 23 February 2015
It is indicated that non-LAR subtypes of TNBC are AR dependent and, moreover, that enzalutamide is a promising targeted therapy for multiple molecular sub types of AR+ TNBC.
Ethanol consumption modifies dendritic cell antigen presentation in mice.
- Richard E. Heinz, C. Waltenbaugh
- Biology, MedicineAlcoholism: Clinical and Experimental Research
- 1 October 2007
Ethanol alters CD11c+CD8(alpha)+ DC function, affecting cytokines responsible for adaptive immune responses, and a unifying hypothesis for the underlying mechanism(s) of ethanol's effect upon adaptive immune function is proposed.
Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis
- Richard E. Heinz, M. Rudolph, J. Richer
- BiologyDevelopment
- 15 November 2016
The hypothesis that a synchronized decrease in miRNAs, such as miR-150, at late pregnancy serves to allow translation of targets crucial for lactation is supported.
Patterns of Sex Steroid Hormones in Nipple Aspirate Fluid during the Menstrual Cycle and after Menopause in Relation to Serum Concentrations
- R. Chatterton, S. Khan, Richard E. Heinz, D. Ivancic, O. Lee
- Biology, MedicineCancer Epidemiology, Biomarkers and Prevention
- 1 January 2010
This is the first description of the temporal relationships of sex steroids in NAF and serum relative to the menstrual cycle and insights into the lack of correlation of Naf and breast tissue estrogens with serum estrogens are provided, and new hypotheses are generated.
Hormonal Determinants of Nipple Aspirate Fluid Yield among Breast Cancer Cases and Screening Controls
- A. Fought, C. McGathey, S. Khan
- Medicine, BiologyCancer Epidemiology, Biomarkers and Prevention
- 18 September 2013
NAF-yielders show higher prolactin than non-y yielders, regardless of menopause and parity; implications of this and other endocrine differences on NAF biomarkers of breast cancer risk deserve further study.
Methodological considerations in estrogen assays of breast fluid and breast tissue
- R. Chatterton, M. Muzzio, Richard E. Heinz, P. Gann, S. Khan
- MedicineSteroids
- 1 July 2015
CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress
- O. Balcioglu, Richard E. Heinz, B. Spike
- Biology, MedicineBreast Cancer Research
- 13 November 2020
Results presented here indicate that targeting CRIPTO with ALK4 L75A -Fc may have potential as a therapy since it inhibits breast cancer cell adaptation to microenvironmental challenges and associated stem-like and EMT phenotypes.
Breast Hormone Concentrations in Random Fine-Needle Aspirates of Healthy Women Associate with Cytological Atypia and Gene Methylation
- O. Lee, Richard E. Heinz, S. Khan
- Medicine, BiologyCancer Prevention Research
- 28 June 2018
The authors' data indicate that future larger studies of breast steroid hormones along with other parameters are feasible, and significant associations of breast androgen concentrations with breast density and gene methylation warrant future study.
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