Richard D. Mathewson

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A cell-based high-throughput screen to identify small molecular weight stimulators of the innate immune system revealed substituted pyrimido[5,4-b]indoles as potent NFκB activators. The most potent hit compound selectively stimulated Toll-like receptor 4 (TLR4) in human and mouse cells. Synthetic modifications of the pyrimido[5,4-b]indole scaffold at the(More)
A light and electron microscopic study was performed to determine age changes in Meissner corpuscles. In forepaw digital pads of mice aged to their maximum life expectancy, corpuscles were found to increase in size and complexity until middle age, and then to become smaller, disorganized and lobulated with more advanced age. Nerve terminals at more advanced(More)
Investigation focused on finding qualitative and quantitative evidence of age-changes in the quantity of neural surface within Meissner corpuscles. These mechanoreceptors were studied in 53 mice (nine age-groups) ranging from 1.7 to 24 months old. Forepaw digital pads were formalin-fixed and frozen-sectioned parallel to each digit and perpendicular to the(More)
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