Richard D. Irwin

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Montréal. Il a pour mission la promotion et la valorisation de la recherche. Érudit offre des services d'édition numérique de documents scientifiques depuis 1998. Note : les règles d'écriture des références bibliographiques peuvent varier selon les différents domaines du savoir. Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des(More)
This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological(More)
Montréal. Il a pour mission la promotion et la valorisation de la recherche. Érudit offre des services d'édition numérique de documents scientifiques depuis 1998. Note : les règles d'écriture des références bibliographiques peuvent varier selon les différents domaines du savoir. Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des(More)
There is increasing use of transcriptional profiling in hepatotoxicity studies in the rat. Understanding hepatic gene expression changes over time is critical, since tissue collection may occur throughout the day. Furthermore, when comparing results from different data sets, times of dosing and tissue collection may vary. Circadian effects on the mouse(More)
Acknowledgements We benefited from comments Abstract We show how one can specify micro-level hazard models of adoption that separately represent the awareness and evaluation/choice stage of the adoption decision process even when one observes only the final outcome, i.e. adoption or not. These models can be derived from random utility theory. Using a small(More)
The aliphatic hexacarbons n-hexane, methyl-n-butyl ketone, and 2,5-hexanedione are known to produce a peripheral neuropathy that involves an accumulation of 10-nm neurofilaments above the nodes of Ranvier in the spinal cord and peripheral nerve. In this study, rats were treated with 0.5% 2,5-hexanedione in drinking water for 180 days, and their spinal cord(More)
BACKGROUND Recently, microarray data analyses using functional pathway information, e.g., gene set enrichment analysis (GSEA) and significance analysis of function and expression (SAFE), have gained recognition as a way to identify biological pathways/processes associated with a phenotypic endpoint. In these analyses, a local statistic is used to assess the(More)
l concerning the relationship of U.S. companies' entry strategies into overseas country markets and those countries' positions along an environmental "temperature gradient". Although Litvak and Banting's original hypothesis was put forth to explain why international agent middlemen evolve into merchant middlemen, the analytical framework is relevant to(More)
Risk Theory in 1901 From time to time, the Committee on the Theory of Risk will be reprinting classic papers (or in this case a book) on risk theory. What follows is the committee's first submission of this series. was originally published in 1901. It was reprinted in 1951 by the S.S. Huebner Foundation for Insurance Education. As stated in the forward of(More)