Richard D Irwin

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This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological(More)
  • Ouvrage Recensé, William Foote Whyte, Edith L Hamilton, Richard D Irwin, Ronald Pleau
  • 2015
Montréal. Il a pour mission la promotion et la valorisation de la recherche. Érudit offre des services d'édition numérique de documents scientifiques depuis 1998. Note : les règles d'écriture des références bibliographiques peuvent varier selon les différents domaines du savoir. Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des(More)
BACKGROUND Recently, microarray data analyses using functional pathway information, e.g., gene set enrichment analysis (GSEA) and significance analysis of function and expression (SAFE), have gained recognition as a way to identify biological pathways/processes associated with a phenotypic endpoint. In these analyses, a local statistic is used to assess the(More)
Background. The adult mammalian retina is an important model in research on the central nervous system. Many experiments require the combined use of genetic manipulation, imaging, and electrophysiological recording, which make it desirable to use an in vitro preparation. Unfortunately, the tissue culture of the adult mammalian retina is difficult, mainly(More)
  • Andrew F Haughwout, Robert P Inman, Steven Craig, Thomas Luce, Howard Chernick, Joe Gyourko +11 others
  • 2003
Association meetings. The research and views presented here are those of the authors alone and do not reflect the official position of the Federal Reserve Bank of New York or the NBER. Short sections of text not to exceed two paragraphs, may be quoted without explicit permission provided that full credit including ©notice, is given to the source. ABSTRACT(More)
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