Richard Caprioli

Lawrence S. Prince1
Alvin C Powers1
1Lawrence S. Prince
1Alvin C Powers
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The present studies extend recent findings that mice null for the alpha(2A) adrenergic receptor (alpha(2A) AR KO mice) lack suppression of exogenous secretagogue-stimulated insulin secretion in response to alpha(2) AR agonists by evaluating the endogenous secretagogue, glucose, ex vivo, and providing in vivo data that baseline insulin levels are elevated(More)
Interferon regulatory factor 6 (IRF6) encodes a highly conserved helix-turn-helix DNA binding protein and is a member of the interferon regulatory family of DNA transcription factors. Mutations in IRF6 lead to isolated and syndromic forms of cleft lip and palate, most notably Van der Woude syndrome (VWS) and Popliteal Ptyerigium Syndrome (PPS). Mice lacking(More)
Visualization and differentiation of proteins in tissue are problems of increasing interest in computational systems biology, bioinformatics, and image processing. A platform for generating such proteomic information is matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). In imaging MALDI-MS, spatial information and protein expression(More)
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