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Metformin Exhibits Radiation Countermeasures Efficacy When Used Alone or in Combination with Sulfhydryl Containing Drugs
TLDR
Metformin alone or in combination with selected sulfhydryl agents possesses radioprotective properties when administered 24 h after radiation exposure comparable to that observed for amifostine administered 30 min prior to irradiation making it a potentially useful agent for radiation countermeasures use. Expand
Prevalence of new maternal alloantibodies after intrauterine transfusion for severe Rhesus disease.
TLDR
Induction of additional maternal red cell alloantibodies after treatment for severe Rh disease is relatively common and may have significant implications for future pregnancies in this high-risk population. Expand
Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity.
TLDR
A unique survivin-associated adaptive response in which increased radiation resistance or sensitization of cells can be induced by exposure to 5mGy or to the reactive oxygen species (ROS) generating drug Emodin (1,3,8-trihydroxy-6-methylanthraquinone), a naturally occurring anthraquinones. Expand
TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response
TLDR
A survivin-associated radio-adaptive response was induced by exposure to 5 mGy of ionizing radiation and was correlated to the TP53 mutational status of exposed cells, indicating a role for intercellular signaling by reactive oxygen species (ROS). Expand
Ultrasonographic measurement of fetal nuchal skin to screen for chromosomal abnormalities
TLDR
Nuchal skin thickness is a useful noninvasive measurement to screen for Down syndrome but does not help to identify fetuses with other chromosomal abnormalities. Expand
Prenatal Sonographic Diagnosis of Hemivertebrae
TLDR
Most fetuses with prenatally diagnosed hemivertebrae have additional anomalies, often syndromic, which affect the prognosis, and affected pregnancies have high rates of cesarean delivery and growth restriction. Expand
A Manganese Superoxide Dismutase (SOD2)-Mediated Adaptive Response
TLDR
While very low radiation doses require an intact TNF signaling process to induce a SOD2-mediated adaptive response, amifostine can induce a similar adaptive response in both TNF receptor competent and knockout cells, respectively. Expand
Pregnancy complicated by triploidy: a comparison of the three karyotypes.
TLDR
There are significant abnormalities detected during prenatal sonography in most all clinically recognized cases of triploidy, and sonography cannot reliably distinguish between the 69,XXY and 69,XXX karyotypes. Expand
Sonographic Findings of Trisomy 18 in the Second Trimester of Pregnancy
TLDR
Targeted sonography identified abnormal fetal anatomy or abnormal biometric findings in 97% of fetuses with trisomy 18 in the second trimester of pregnancy. Expand
A vitamin A analogue inhibits radiation-induced oncogenic transformation
TLDR
It is investigated here the possibility that retinoids might also inhibit radiation-induced oncogenic transformation using a cell line of C3H mouse embryo fibroblasts grown in culture, and a marked reduction in the transformation frequency is reported. Expand
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