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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
TLDR
The GINS (go ichi ni san) complex allows the MCM (minichromosome maintenance) helicase to interact with key regulatory proteins in large replisome progression complexes (RPCs) that are assembled during initiation and disassembled at the end of S phase. Expand
A key role for Ctf4 in coupling the MCM2‐7 helicase to DNA polymerase α within the eukaryotic replisome
TLDR
It is shown that cells lacking both Ctf4 and Mrc1 experience chronic activation of the DNA damage checkpoint during chromosome replication and do not complete the cell cycle, indicating that coupling MCM2‐7 to replicative polymerases is an important feature of the regulation of chromosome replication in eukaryotes. Expand
Complete and Integrated Pyrene Degradation Pathway in Mycobacterium vanbaalenii PYR-1 Based on Systems Biology
TLDR
Analysis of pyrene metabolism in M. vanbaalenii PYR-1 indicates that this bacterium degrades pyrene to central intermediates through o-phthalate and the beta-ketoadipate pathway. Expand
Eukaryotic replisome components cooperate to process histones during chromosome replication.
TLDR
The data indicate that the eukaryotic replication and transcription machineries use analogous assemblies of multiple chaperones to preserve chromatin integrity. Expand
Proximal femoral degeneration in growing broiler fowl.
TLDR
The term proximal femoral degeneration (PFD) was adopted and Histological examination showed that PFD was most frequently due to a bacterial chondritis and osteomyelitis, with frequent involvement of surrounding tissues. Expand
Viral respiratory diseases (ILT, aMPV infections, IB): are they ever under control?11
TLDR
None of the three diseases described can claim to be satisfactorily controlled and it remains to be seen whether the newer generations of vaccines will be more efficacious and cost effective. Expand
Molecular Cloning and Expression of Genes Encoding a Novel Dioxygenase Involved in Low- and High-Molecular-Weight Polycyclic Aromatic Hydrocarbon Degradation in Mycobacterium vanbaalenii PYR-1
TLDR
The upregulation of nidA3B3 in M. vanbaalenii PYR-1 induced by PAHs was confirmed by reverse transcription-PCR analysis and close similarities to the corresponding PAH ring-hydroxylating dioxygenases from Mycobacterium and Rhodococcus were revealed. Expand
A Polyomic Approach To Elucidate the Fluoranthene-Degradative Pathway in Mycobacterium vanbaalenii PYR-1
TLDR
Mycobacterium vanbaalenii PYR-1 is capable of degrading a wide range of high-molecular-weight polycyclic aromatic hydrocarbons (PAHs), including fluoranthene, and metabolic information with the genomic and proteomic results and proposed pathways for the degradation are integrated. Expand
SUMOylation of the GTPase Rac1 is required for optimal cell migration
TLDR
It is identified that the small ubiquitin-like modifier E3-ligase, PIAS3, interacts with Rac1 and is required for increased Rac activation and optimal cell migration in response to hepatocyte growth factor (HGF) signalling, and a role for SUMO in the regulation of cell migration and invasion is revealed. Expand
MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract*
TLDR
It is shown that prior to replication initiation, Mcm2-7 is present at licensed replication origins in a complex with a molecular mass close to double that of the Mcm 2-7 hexamer, which provides a configuration potentially capable of initiating a pair of bidirectional replication forks in S phase. Expand
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