Richard C. Seagrave

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Results of animal experiments using sinusoidal changes in inspired halothane concentration showed that the ratio of variation in end-expired concentration to the variation in inspired concentration reached a plateau in the Bode diagram. With the help of an uptake and distribution model, the interpretation of the results showed that the level of the plateau(More)
Extreme whole-body hyperthermia was achieved without lasting side effects in canines by elevating body core temperature to 42 degrees C, using a warm water bath. Cold water irrigation of the nasal alar fold permitted an additional core temperature elevation of 0.5-1.0 degrees C above brain temperature for periods up to 1.5 h. The brain-core temperature(More)
A quantitative phenomenological model to describe the relationships between biomass growth rate, oxygen consumption, and heat production in developing embryos has been developed and tested using a wide range of experimental data. The model employs generalized material and energy balances, principles of enzyme kinetics, and an overall metabolic model scheme(More)
When one is exposed to microgravity, fluid which is normally pooled in the lower extremities is redistributed headward and weight bearing bones begin to demineralize due to reduced mechanical stresses. The kidney, which is the primary regulator of body fluid volume and composition, responds to the fluid shift and bone demineralization by increasing the(More)
The eggs of the Megapodiidae are incubated while buried in a substrate with which they exchange heat and water. The eggs may be buried in sand or in a mound composed in part or totally of organic material. We have analyzed the heat and water exchange of these buried eggs by constructing egg heat and mass balances. The equations are used to examine changes(More)
Generalized material and energy balances are presented for biological systems that experience negligible kinetic, elastic, and potential energy changes. The balances are used to characterize the mass changes and energy transformations that occur in the developing avian embryo, using as an example a consistent set of data for the chicken egg. It is shown(More)
Differences in dietary fats cause differences in cholesterol metabolism in mice. CBA/J mice are resistant to diet-induced hypercholesterolemia and atherosclerosis; they adjust hepatic hydroxymethyl-glutaryl-CoA reductase activity (HMGR) to maintain homeostasis; C57BR/cdJ mice are susceptible, but young animals are thought to maintain homeostasis by changing(More)