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The "Landmark Task" is designed to tease apart two major factors in determining line bisection errors in spatial neglect: one whose general nature is perceptual, the other whose nature is motor. On critical test trials, the subject is required to point to whichever end of a mid-transected line is judged as nearer to the transection. Seven out of eight(More)
OBJECTIVES To determine the risk of epileptic seizures due to a brain arteriovenous malformation (AVM) or cavernous malformation (CM). METHODS In a prospective population-based study of new diagnoses of AVMs (n = 229) or CMs (n = 139) in adults in Scotland in 1999-2003, we used annual medical records surveillance, general practitioner follow-up, and(More)
The rightward line bisection errors made by patients with visuospatial neglect can be explained as due to a spatially misdirected response, which would be predicted on either of two accounts. An alternative view, however, is that such patients actually misperceive the left half of a horizontal line as being shorter than the right half. We have tested this(More)
Event-related potentials (ERPs) were recorded during a continuous recognition memory task for visually presented words, with a 6 item lag between the first and second presentation of each word. The subjects consisted of: (i) a control group of patients with primary generalized epilepsy; (ii) patients who had undergone either a left or a right anterior(More)
The limb-girdle muscular dystrophies are a group of disorders with wide genetic and clinical heterogeneity. Recently, mutations in the ANO5 gene, which encodes a putative calcium-activated chloride channel belonging to the Anoctamin family of proteins, were identified in five families with one of two previously identified disorders, limb-girdle muscular(More)
The changes in postural tremor of the hand produced by moderate cooling of the muscles of one forearm have been investigated in 16 normal subjects and in 16 patients with essential tremor. In both groups, cooling produced a profound long lasting decrease in tremor level of the ipsilateral hand. In normal subjects, although cooling reduced the tremor size,(More)
Event-related potentials (ERPs) were recorded during a task requiring continuous recognition memory for visually-presented words. Twelve subjects each performed the task twice, once following the administration of scopolamine, and once after receiving a saline placebo. In the placebo condition, correctly detected "old" words (i.e., words that had been(More)
Groups of patients with left or right unilateral cerebral stroke were tested for their ability to reach either toward a single visual target or midway between 2 targets. The tasks were performed both in free vision and in conditions preventing visual feedback from the hand. It was found that only the right CVA patients were inaccurate in reaching, and only(More)
BACKGROUND AND PURPOSE Intracranial vascular malformations (IVMs) are an important cause of intracranial hemorrhage, epilepsy, and long-term disability in adults. There are no published prospective, population-based studies dedicated to the detection of any type of IVM (cavernous malformations, venous malformations, and arteriovenous malformations [AVMs] of(More)
BACKGROUND Cerebral cavernous malformations (CCMs) are prone to bleeding but the risk of intracranial haemorrhage and focal neurological deficits, and the factors that might predict their occurrence, are unclear. We aimed to quantify these risks and investigate whether they are affected by sex and CCM location. METHODS We undertook a population-based(More)