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Surface-based brain imaging analysis is increasingly being used for detailed analysis of the topology of brain activation patterns and changes in cerebral gray matter. Here we present SUMA, a new interface for visualizing and performing surface-based brain imaging analysis that is tightly coupled to AFNI – a volume-based brain imaging analysis suite. The(More)
CONTEXT Amygdala and ventrolateral prefrontal cortex (vlPFC) dysfunction manifests in adolescents with anxiety disorders when they view negatively valenced stimuli in threatening contexts. Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening. OBJECTIVE(More)
Artifactual sources of resting-state (RS) FMRI can originate from head motion, physiology, and hardware. Of these sources, motion has received considerable attention and was found to induce corrupting effects by differentially biasing correlations between regions depending on their distance. Numerous corrective approaches have relied on the identification(More)
The neurophysiological basis for stuttering may involve deficits that affect dynamic interactions among neural structures supporting fluid speech processing. Here, we examined functional and structural connectivity within corticocortical and thalamocortical loops in adults who stutter. For functional connectivity, we placed seeds in the left and right(More)
The Functional Imaging Analysis Contest (FIAC) datasets were analyzed with the AFNI software package. Two types of linear regression analyses were carried out: "fixed shape" hemodynamic response, where a preselected incomplete gamma function is used to model each brief activation episode, and "variable shape" analysis, where the temporal shape of the(More)
UNLABELLED In humans, there is a repeated category-selective organization across the lateral and ventral surfaces of the occipitotemporal cortex. This apparent redundancy is often explained as a feedforward hierarchy, with processing within lateral areas preceding the processing within ventral areas. Here, we tested the alternative hypothesis that this(More)
Recent research on classical fear-conditioning in the anxiety disorders has identified overgeneralization of conditioned fear as an important conditioning correlate of anxiety pathology. Unfortunately, only one human neuroimaging study of classically conditioned fear generalization has been conducted, and the neural substrates of this clinically germane(More)
Brain function in "resting" state has been extensively studied with functional magnetic resonance imaging (FMRI). However, drawing valid inferences, particularly for group comparisons, is fraught with pitfalls. Differing levels of brain-wide correlations can confound group comparisons. Global signal regression (GSReg) attempts to reduce this confound and is(More)
OBJECTIVE Irritability is common in children and adolescents and is the cardinal symptom of disruptive mood dysregulation disorder, a new DSM-5 disorder, yet its neural correlates remain largely unexplored. The authors conducted a functional MRI study to examine neural responses to frustration in children with severe mood dysregulation. METHOD The authors(More)
Functional neuroimaging has shown that multiple brain regions are active during volitional swallowing. Little is known, however, about which regions integrate motor execution and sensory feedback in the swallowing system. Although unilateral brain lesions in either hemisphere can produce swallowing deficits, some functional neuroimaging studies indicate(More)