Richard C. Lewis

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For an accurate definition of the anatomic limits of the carpal tunnel, 26 cadaver upper extremities were studied by gross (10), histologic (3), and radiographic (13) methods. The mean proximal limit of the central portion of the flexor retinaculum was 11 mm distal to the capitate-lunate joint, and the mean distal limit of the distal portion was 10 mm(More)
We used segments of the lateral antebrachial cutaneous nerve to graft defects in forty-two digital nerves in thirty-five patients. Age was a more important prognostic indicator for functional sensibility than either the length of the nerve graft or the time-interval from injury to grafting. The younger patients did better. A battery of eight tests was used(More)
A 100- to 3200-mg dose range of FCE 22,178 was studied in this phase I single-dose escalation safety/kinetics study. After oral administration, a rapid drug absorptive phase and a biexponential disposition profile were observed. Mean estimates of the terminal elimination half-life of FCE 22,178, over the doses studied, ranged from 7.6 to 14.4 hours. A(More)
Sensitive HPLC-UV methodology has been developed and validated for quantitating rifabutin, an antimycobacterial, and its 25-desacetyl metabolite, LM-565, in human plasma and urine. The HPLC separation for both plasma and urine samples was performed on an ODS, 5-µm, reverse-phase column (25 cm × 4.6-cm ID) using a mobile phase of acetonitrile/0.05 M(More)
A technique for arthrodesis of small joints of the hand is described that uses a tenon to secure apposition that has good intrinsic stability as well as a large surface area of cancellous bony contact. A minimum of postoperative immobilization is required. The tenon arthrodesis method has been employed in 85 joints. The literature shows pseudoarthrosis(More)
Carpal tunnel syndrome is one of the most common problems seen by the hand surgeon. In spite of its frequent occurrence there are several aspects of its treatment that remain controversial. A survey of the members of the American Society for Surgery of the Hand determined whether a consensus exists concerning the treatment of carpal tunnel syndrome among(More)
Magnetic resonance imaging (MRI) was used to determine cross-sectional areas and volumes of carpal canals and carpal canal contents in five cadaver specimens in an assessment of the reliability of MRI for establishing contents/canal ratios. Volumes of the carpal canals and their contents were accurately calculated from MRI with a previously described(More)