Richard C. G. Holland

Learn More
Biologists need to perform complex queries, often across a variety of databases. Typically, each data resource provides an advanced query interface, each of which must be learnt by the biologist before they can begin to query them. Frequently, more than one data source is required and for high-throughput analysis, cutting and pasting results between(More)
SUMMARY BioJava is a mature open-source project that provides a framework for processing of biological data. BioJava contains powerful analysis and statistical routines, tools for parsing common file formats and packages for manipulating sequences and 3D structures. It enables rapid bioinformatics application development in the Java programming language. (More)
The Ensembl project (http://www.ensembl.org) is a comprehensive genome information system featuring an integrated set of genome annotation, databases, and other information for chordate, selected model organism and disease vector genomes. As of release 51 (November 2008), Ensembl fully supports 45 species, and three additional species have preliminary(More)
The Ensembl project (http://www.ensembl.org) is a comprehensive genome information system featuring an integrated set of genome annotation, databases and other information for chordate and selected model organism and disease vector genomes. As of release 47 (October 2007), Ensembl fully supports 35 species, with preliminary support for six additional(More)
We set out to determine the effects of pharmacist-led medication review in older people by means of a systematic review and meta-analysis covering 11 electronic databases. Randomized controlled trials in any setting, concerning older people (mean age > 60 years), were considered, aimed at optimizing drug regimens and improving patient outcomes. Our primary(More)
OBJECTIVE To determine whether home based medication review by pharmacists affects hospital readmission rates among older people. DESIGN Randomised controlled trial. SETTING Home based medication review after discharge from acute or community hospitals in Norfolk and Suffolk. PARTICIPANTS 872 patients aged over 80 recruited during an emergency(More)
OBJECTIVE To assess whether home-based medication review by a pharmacist for at-risk older patients in a primary care setting can reduce hospital admissions. DESIGN Randomised controlled trial comparing home-based medication review with standard care. SETTING Home-based medication review of 136 patients registered with one general practice. METHOD(More)
OBJECTIVE To test whether a drug review and symptom self management and lifestyle advice intervention by community pharmacists could reduce hospital admissions or mortality in heart failure patients. DESIGN Randomised controlled trial. SETTING Home based intervention in heart failure patients. PARTICIPANTS 293 patients diagnosed with heart failure(More)
BACKGROUND Viral warts are a common skin condition, which can range in severity from a minor nuisance that resolve spontaneously to a troublesome, chronic condition. Many different topical treatments are available. OBJECTIVES To evaluate the efficacy of local treatments for cutaneous non-genital warts in healthy, immunocompetent adults and children. (More)
OBJECTIVE To determine the impact of multidisciplinary interventions on hospital admission and mortality in heart failure. DESIGN Systematic review. Thirteen databases were searched and reference lists from included trials and related reviews were checked. Trial authors were contacted if further information was required. SETTING Randomised controlled(More)