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BACKGROUND Biologists need to perform complex queries, often across a variety of databases. Typically, each data resource provides an advanced query interface, each of which must be learnt by the biologist before they can begin to query them. Frequently, more than one data source is required and for high-throughput analysis, cutting and pasting results(More)
OBJECTIVE To determine the impact of multidisciplinary interventions on hospital admission and mortality in heart failure. DESIGN Systematic review. Thirteen databases were searched and reference lists from included trials and related reviews were checked. Trial authors were contacted if further information was required. SETTING Randomised controlled(More)
The Ensembl project (http://www.ensembl.org) is a comprehensive genome information system featuring an integrated set of genome annotation, databases, and other information for chordate, selected model organism and disease vector genomes. As of release 51 (November 2008), Ensembl fully supports 45 species, and three additional species have preliminary(More)
OBJECTIVE To determine whether home based medication review by pharmacists affects hospital readmission rates among older people. DESIGN Randomised controlled trial. SETTING Home based medication review after discharge from acute or community hospitals in Norfolk and Suffolk. PARTICIPANTS 872 patients aged over 80 recruited during an emergency(More)
OBJECTIVE To explore the advice giving role of pharmacists during consultation for medication review with patients aged 80 or more. DESIGN Discourse analysis. SETTING Participants' homes. PARTICIPANTS Subsample of consultations within a large randomised trial of home medication review among patients aged 80 or more who had been admitted to hospital.(More)
OBJECTIVE To investigate the agreement between direct and indirect comparisons of competing healthcare interventions. DESIGN Meta-epidemiological study based on sample of meta-analyses of randomised controlled trials. Data sources Cochrane Database of Systematic Reviews and PubMed. Inclusion criteria Systematic reviews that provided sufficient data for(More)
BACKGROUND Tuberculosis notification rates for London have risen dramatically in recent years. Molecular typing of Mycobacterium tuberculosis has contributed to our understanding of the epidemiology of tuberculosis throughout the world. This study aimed to assess the degree of recent transmission of M tuberculosis in London and subpopulations of the(More)
We set out to determine the effects of pharmacist-led medication review in older people by means of a systematic review and meta-analysis covering 11 electronic databases. Randomized controlled trials in any setting, concerning older people (mean age > 60 years), were considered, aimed at optimizing drug regimens and improving patient outcomes. Our primary(More)
BACKGROUND Viral warts are a common skin condition, which can range in severity from a minor nuisance that resolve spontaneously to a troublesome, chronic condition. Many different topical treatments are available. OBJECTIVES To evaluate the efficacy of local treatments for cutaneous non-genital warts in healthy, immunocompetent adults and children. (More)
UNLABELLED BioJava is an open-source project for processing of biological data in the Java programming language. We have recently released a new version (3.0.5), which is a major update to the code base that greatly extends its functionality. RESULTS BioJava now consists of several independent modules that provide state-of-the-art tools for protein(More)