Richard Body

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OBJECTIVES This paper sought to evaluate whether high sensitivity troponin (hs-cTnT) can immediately exclude acute myocardial infarction (AMI) at a novel 'rule out' cut-off. BACKGROUND Subgroup analysis of recent evidence suggests that undetectable hs-cTnT may exclude AMI at presentation. METHODS In a cohort study, we prospectively enrolled patients(More)
This paper describes a prototype clinical decision support system (CDSS) for risk stratification of patients with cardiac chest pain. A newly developed belief rule-based inference methodology-RIMER was employed for developing the prototype. Based on the belief rule-based inference methodology, the prototype CDSS can deal with uncertainties in both clinical(More)
The number of neurons, astrocytes, reactive glia, oligodendrocytes, endothelia, and pericytes in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl mercury (MeHg) and mercuric chloride (inorganic mercury; IHg) has been estimated by use of the optical volume fractionator stereology(More)
The Guidelines in Emergency Medicine Network (GEMNet) has been created to promote best medical practice in a range of conditions presenting to emergency departments (EDs) in the UK. This guideline presents a summary of the best available evidence to guide the management of adult patients who present to the ED following an overdose of tricyclic(More)
The distribution of accumulated inorganic mercury deposits in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl-mercury (MeHg) and mercuric chloride (inorganic mercury-IHg) has been determined by autometallography. Four groups of monkeys were exposed to MeHg (50 micrograms Hg/kg body(More)
The effects of long-term subclinical exposure to methylmercury on the number of neurons, oligodendrocytes, astrocytes, microglia, endothelial cells and pericytes within the thalamus from the left side of the brain of the monkey Macaca fascicularis has been determined by use of the Optical Volume Fractionator stereological method. The accumulated burden of(More)
OBJECTIVE To evaluate the incidence of major adverse cardiac events (MACE) at 1 year in emergency department (ED) patients with possible acute coronary syndromes, stratified by high sensitivity troponin (hs-cTnI) concentrations using sex-specific cut points compared with overall cut points. METHODS In a multicentre observational study of 2841 patients,(More)
Many accounts of autism spectrum disorder (ASD) imply that the condition's behavioural 'symptoms' are direct reflexes of underlying deficits. In doing so, however, they invariably overlook the social contexts in which symptomatic behaviours occur and are identified as pathological. This study addresses this issue, using conversation analysis (CA) to examine(More)
Congenital low-dose exposure of rat fetuses to methylmercury produced smaller offspring without anatomical abnormalities. The present study explored the mechanisms of the smallness of fetuses. The pregnant rats were given methylmercury water (25 ppm) from day 1 of pregnancy continuously until day 20 of gestation. There was a negative correlation of fetal(More)
Diagnosis is arguably the cornerstone of medicine. Without at least some form of diagnosis the practice of medicine would not be possible. This narrative review explores common philosophical assumptions and challenges the notion that a certain diagnosis can ever be made. The idealistic concept of "primum non nocere" is discussed, and whether the utilitarian(More)