Richard Albert

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Inhalation of antigen in immunized mice induces an infiltration of eosinophils into the airways and increased bronchial hyperreactivity as are observed in human asthma. We employed a model of late-phase allergic pulmonary inflammation in mice to address the role of leukotrienes (LT) in mediating airway eosinophilia and hyperreactivity to methacholine.(More)
Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability worldwide. The Global Burden of Disease study has concluded that COPD will become the third leading cause of death worldwide by 2020, and will increase its ranking of disability-adjusted life years lost from 12th to 5th. Acute exacerbations of COPD (AECOPD) are(More)
BACKGROUND Many patients with chronic obstructive pulmonary disease (COPD) suffer from poor sleep quality. We hypothesized that poor sleep quality in otherwise stable patients predicted exacerbations in these patients. METHODS This is a secondary analysis of the results of a previously published randomized trial of azithromycin in 1,117 patients with(More)
Vile. I am grateful for the useful suggestions and criticisms I received from the three anonymous external reviewers who recommended this submission for publication. I have also benefitted from presenting earlier versions of The current scholarly focus on informal constitutional amendment has obscured the continuing relevance of formal amendment rules. In(More)