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Rationale: Preliminary unpublished studies in our laboratory suggested that the behaviour of Sprague-Dawley (SD) and Dark Agouti (DA) rats was markedly different on both the elevated plus maze and in(More)
Rationale: Decreased 5-HT function has been shown to induce behaviour consistent with an "anxiolytic" effect. Administration of a single dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy"(More)
Rationale: 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") administration produces neurotoxic degeneration of 5-HT nerve endings in several regions of rat brain. Administration of the GABAmimetic(More)
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