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  • Dawn E. Ouelle, Frédérique Zindy, Richard A. Ashmun, Charles J Sherr
  • Medicine, Biology
  • Cell
  • 1995 (First Publication: 1 December 1995)
  • The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the retinoblastoma protein (pRB) and prevents exitContinue Reading
  • Hirokazu Hirai, Martine F Roussel, Jun-ya Kato, Richard A. Ashmun, Charles J Sherr
  • Biology, Medicine
  • Molecular and cellular biology
  • 1995 (First Publication: 1 May 1995)
  • Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two novel members of the mouse INK4 gene family, p19 and p18, thatContinue Reading