Richard A. O'Connor

Stephen M. Anderton2
Stephen M Anderton2
2Stephen M. Anderton
2Stephen M Anderton
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The use of modern hardware-description languages in the chip design process has allowed designs to be modeled at higher abstraction levels. More powerful modeling styles, such as register-transfer and behavioral level specifications, have spurred the development of high-level synthesis techniques in both industry and academia. However, despite the many(More)
T cells that produce both IL-17 and IFN-γ, and co-express ROR-γt and T-bet, are often found at sites of autoimmune inflammation. However, it is unknown whether this co-expression of T-bet with ROR-γt is a prerequisite for immunopathology. We show here that T-bet is not required for the development of Th17-driven experimental autoimmune encephalomyelitis(More)
  • Emily J. Colbeck, James P. Hindley, Kathryn Smart, Emma Jones, Anja Bloom, Hayley Bridgeman +8 others
  • 2015
Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely of CXCR3(+) T-bet(+) 'TH1-like' Tregs which are thymus-derived Helios(+) cells. Whilst IL-2 maintains(More)
  • Ben C Reynolds, Darryl G Turner, Rhoanne C McPherson, Catriona T Prendergast, Richard G Phelps, Neil A Turner +2 others
  • 2014
Interest in manipulating the immunosuppressive powers of Foxp3-expressing T regulatory cells as an immunotherapy has been tempered by their reported ability to produce proinflammatory cytokines when manipulated in vitro, or in vivo. Understanding processes that can limit this potentially deleterious effect of Treg cells in a therapeutic setting is therefore(More)
CD4+ T cells acquire membrane fragments from antigen-presenting-cells via a process termed trogocytosis. Identifying which CD4+ T cells undergo trogocytosis in co-culture with Ag-loaded APC can enrich for antigen-reactive T cells without knowledge of their fine specificity or cytokine-production profiles. We sought to assess the suitability of this method(More)
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