This study aims to design epitope-based peptides for the utility of vaccine development by targeting Glycoprotein 2 (GP2) and Viral Protein 24 (VP24) of the Ebola virus (EBOV) that, respectively, facilitate attachment and fusion of EBOV with host cells. Using various databases and tools, immune parameters of conserved sequences from GP2 and VP24 proteins of… (More)
Children infected with human immunodeficiency virus (HIV) have an increased risk of malignancies. Herein, we present a 16 month old HIV infected child receiving antiretroviral therapy who presented with pain and swelling of both knees and ankles. This child was diagnosed as Langerhans cell histiocytosis (LCH) which is an uncommon proliferative disorder… (More)
Cancer is the second leading cause of death worldwide, the deaths are projected to continue rising, with an estimated 12 million deaths in 2030. The aim of the present investigation is to prepare and compare the uncoated (U-CH NP) and eudragit S 100-coated (E-U-CH NP) chitosan nanoparticles encapsulating a caspase 3 activator (UCN 01), by ionic gelation… (More)
Cubosomes encapsulating fluconazole were prepared by emulsification method and characterized for particle size, entrapment efficiency, SEM, in vitro release, skin irritation studies, and confocal laser scanning microscopy. The cubosomes prepared were 257.2 ± 2.94 nm in size and with drug entrapment efficiency of 66.2 ± 2.69 %. The prepared formulation was… (More)
Negative pressure pulmonary oedema (NPPO) is a life threatening condition, manifested due to upper airway obstruction in a spontaneously breathing patient. Upper airway obstruction caused by classic laryngeal mask airway (cLMA) and ProSeal laryngeal mask airway (PLMA) has been reported, and NPPO has also been reported following the use of cLMA. Search of… (More)
Paratesticular germ cell tumors are extremely rare. A 12-month-old boy with yolk sac tumor involving only the paratesticular tissue is reported. Pre-operatively raised alpha fetoprotein levels fell to normal levels after high inguinal orchiectomy. This appears to be the youngest and only the 3(rd) case reported in the English literature.
Streptomyces exfoliatus CFS 1068, an isolate of crop field soil was tested for its potential to degrade native poultry feathers and to produce proteins and amino acids. The strain caused a net loss of 83 ± 0.7% in feather weight in 6 days at 28°C in shake cultures (150 rpm). The hydrolysate was found to contain 2,100 ± 36 μg ml−1 soluble proteins and 2,090… (More)
In this paper we have presented a scheme for transcod-ing document images for presentation on handheld devices like PDA's, e-books etc. We have proposed technqiues suitable, in particular ,for images of documents of Indian languages having Devanagari based scripts (viz. Hindi, Marathi, Bengali, Assamese, etc). Appropriate compression scheme for textual… (More)