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We study the satisfiability of randomly generated formulas formed by M clauses of exactly K literals over N Boolean variables. For a given value of N the problem is known to be most difficult when α = M/N is close to the experimental threshold α c separating the region where almost all formulas are SAT from the region where all formulas are UNSAT. Recent(More)
We study the satisfiability of random Boolean expressions built from many clauses with K variables per clause (K-satisfiability). Expressions with a ratio alpha of clauses to variables less than a threshold alphac are almost always satisfiable, whereas those with a ratio above this threshold are almost always unsatisfiable. We show the existence of an(More)
Using the cavity we derive the various threshold values for the number of clauses per variable of the random K-satisfiability problem, generalizing the previous results to K ≥ 4. We also give an analytic solution of the equations, and some closed expressions for these thresholds, in an expansion around large K. The stability of the solution is also(More)
Non-deterministic polynomial time (commonly termed`NP-complete') problems are relevant to many computational tasks of practical interestÐsuch as thètravelling salesman problem'Ðbut are dif®cult to solve: the computing time grows exponentially with problem size in the worst case. It has recently been shown that these problems exhibit`phase boundaries',(More)
The evolutionary trajectory of a protein through sequence space is constrained by its function. Collections of sequence homologs record the outcomes of millions of evolutionary experiments in which the protein evolves according to these constraints. Deciphering the evolutionary record held in these sequences and exploiting it for predictive and engineering(More)
It has been shown experimentally that a decimation algorithm based on Survey Propagation (SP) equations allows to solve efficiently some combinatorial problems over random graphs. We show that these equations can be derived as sum-product equations for the computation of marginals in an extended space where the variables are allowed to take an additional(More)
Recent experimental studies indicate that synaptic changes induced by neuronal activity are discrete jumps between a small number of stable states. Learning in systems with discrete synapses is known to be a computationally hard problem. Here, we study a neurobiologically plausible on-line learning algorithm that derives from belief propagation algorithms.(More)
We consider the general problem of finding the minimum weight b-matching on arbitrary graphs. We prove that, whenever the linear programming (LP) relaxation of the problem has no fractional solutions, then the belief propagation (BP) algorithm converges to the correct solution. We also show that when the LP relaxation has fractional solution then BP(More)
External information propagates in the cell mainly through signaling cascades and transcriptional activation, allowing it to react to a wide spectrum of environmental changes. High-throughput experiments identify numerous molecular components of such cascades that may, however, interact through unknown partners. Some of them may be detected using data(More)